Sadamori N, Han T, Block A W, Sandberg A A
Cancer Genet Cytogenet. 1985 May;17(1):69-74. doi: 10.1016/0165-4608(85)90103-7.
Using a sister chromatid differentiation (SCD) technique, cell cycle analysis in lymphocytes from two patients with hairy cell leukemia (HCL) revealed it to be similar to cell cycle progression of normal lymphocytes stimulated with lipopolysaccharide W from Escherichia coli 0.55:B5 (LPS). It appears that LPS can readily stimulate the leukemic cells of HCL into mitosis. In the two cases of B cell HCL studied, one (case 1) was revealed to have an abnormal clone with a missing chromosome #22 that was related to the production of lambda-chains.
运用姐妹染色单体分化（SCD）技术，对两名毛细胞白血病（HCL）患者的淋巴细胞进行细胞周期分析，结果显示其与用大肠杆菌0.55:B5（LPS）的脂多糖W刺激的正常淋巴细胞的细胞周期进程相似。看来LPS能够轻易地刺激HCL的白血病细胞进入有丝分裂。在所研究的两例B细胞HCL中，其中一例（病例1）显示有一个异常克隆，缺少与λ链产生相关的22号染色体。
