Sadamori N, Han T, Kakati S, Sandberg A A
Cancer Genet Cytogenet. 1983 Sep;10(1):67-77. doi: 10.1016/0165-4608(83)90107-3.
What appears to be the first hairy cell leukemia case with a 14q+ anomaly is described. In addition to the 14q+ anomaly, a 6q- and a ring chromosome were seen in a blood sample stimulated with lipopolysaccharide, a B-cell mitogen. The clinical course of the present case was short, stormy, and had a poor response to therapy. The correlation between the clinical course and the presence of a ring chromosome in myelo- and lymphoproliferative blood disorders is discussed in relation to the various blood disorders with this karyotype anomaly described in the literature.
本文描述了首例伴有14q+异常的毛细胞白血病病例。除14q+异常外，在经脂多糖（一种B细胞有丝分裂原）刺激的血样中还发现了一条6q-染色体和一条环状染色体。该病例的临床病程短、病情凶险，且对治疗反应不佳。结合文献中描述的具有这种核型异常的各种血液疾病，讨论了骨髓和淋巴增殖性血液疾病的临床病程与环状染色体存在之间的相关性。
