National Centre for Nanoscience and Nanotechnology, University of Madras, Guindy Campus, Chennai 600025, India.
National Centre for Nanoscience and Nanotechnology, University of Madras, Guindy Campus, Chennai 600025, India.
Mater Sci Eng C Mater Biol Appl. 2018 Sep 1;90:85-94. doi: 10.1016/j.msec.2018.04.040. Epub 2018 Apr 17.
45S5 Bioglass® is the most widely studied class of bioceramic in the field of dental and orthopedics. The present study highlights, one-dimensional bioactive glass nanorods (BGNR) of 45S5 composition synthesized by tuning the parameters of sol-gel process and hybridized with two-dimensional reduced graphene oxide sheets (rGO). BGNR was integrated with rGO by three different methods to form nano hybrids of rGO/BGNR. The prepared BGNR revealed combeite high mineral phase (NaCaSiO) whereas nano hybrids exhibited calcite mineral phase (CaCO) along with combeite in XRD analysis. The morphology, size of BGNR and integration of BGNR with rGO were analyzed using SEM. Nano hybrids were subjected to biological characterizations to identify the bio-activity (mineralization), antibacterial efficacy, hemocompatibility and cell proliferation efficacies. These studies conclude that the one-dimensional BGNR, micron-sized reduced graphene oxide sheet and the calcite phase in nano hybrids play a crucial role in enhancing the bioactivity, antibacterial activity, hemocompatibility and cell proliferation. These findings suggest the synergistic effect of rGO/BGNR nano hybrids will open new venue for biomaterials in the field of implant materials.
45S5 生物玻璃®是牙科和骨科领域研究最广泛的生物陶瓷。本研究重点介绍了通过调整溶胶-凝胶工艺参数合成的一维生物活性玻璃纳米棒（BGNR），并与二维还原氧化石墨烯片（rGO）杂交。通过三种不同的方法将 BGNR 与 rGO 集成，形成 rGO/BGNR 纳米杂化物。制备的 BGNR 显示出钙硅石高矿物相（NaCaSiO），而纳米杂化物在 XRD 分析中显示出方解石矿物相（CaCO）以及钙硅石。使用 SEM 分析了 BGNR 的形态、尺寸以及与 rGO 的集成。对纳米杂化物进行了生物特性研究，以确定生物活性（矿化）、抗菌效果、血液相容性和细胞增殖效果。这些研究表明，一维 BGNR、微米级还原氧化石墨烯片和纳米杂化物中的方解石相在增强生物活性、抗菌活性、血液相容性和细胞增殖方面发挥着关键作用。这些发现表明，rGO/BGNR 纳米杂化物的协同效应将为植入材料领域的生物材料开辟新的途径。
