专题综述系列介绍：DNA 双链断裂修复与途径选择。
Introduction to the Thematic Minireview Series: DNA double-strand break repair and pathway choice.
机构信息
From the Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, Connecticut 06520
出版信息
J Biol Chem. 2018 Jul 6;293(27):10500-10501. doi: 10.1074/jbc.TM118.003212. Epub 2018 May 31.
Abstract
Environmental agents and reactive metabolites induce myriad chromosomal lesions that challenge the integrity of our genome. In particular, the DNA double-strand break (DSB) has the highest potential to cause the types of chromosome aberrations and rearrangements found in transformed and cancer cells. Several conserved pathways of DSB repair exist in eukaryotes, and these have been the subject of intense studies in recent years. In this Thematic Minireview Series, four leading research groups review recent progress in deciphering DSB repair mechanisms and the intricate regulatory network that helps determine the preferential engagement of one pathway over others.
摘要
环境因子和反应性代谢物会诱发大量的染色体损伤，从而挑战我们基因组的完整性。特别是，DNA 双链断裂（DSB）最有可能导致在转化和癌细胞中发现的那种类型的染色体畸变和重排。真核生物中存在几种保守的 DSB 修复途径，近年来这些途径一直是深入研究的主题。在这个专题综述系列中，四个领先的研究小组回顾了近年来在破译 DSB 修复机制和精细调控网络方面的进展，这些机制和网络有助于确定一种途径优先于其他途径的参与。
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