Eliseeva T I, Krasilnikova S V, Geppe N A, Babaev S Yu, Tush E V, Khaletskaya O V, Ovsyannikov D Yu, Balabolkin I I, Ignatov S K, Kubysheva N I
Department of Hospital Pediatrics and Department of ENT Diseases, Nizhny Novgorod State Medical Academy, 10/1 Minin and Pozharsky Square, Nizhny Novgorod 603005, Russia.
Department of Children Diseases, I.M. Sechenov First Moscow State Medical University, 8 Bld. 2 Trubetskaya St., Moscow 119991, Russia.
Can Respir J. 2018 May 8;2018:4835823. doi: 10.1155/2018/4835823. eCollection 2018.
Allergic rhinitis (AR) and allergic rhinosinusitis (ARS) are typical upper airway pathologies (UAP) in children with bronchial asthma (BA) frequently accompanied with nasal obstructive diseases (NOD). In order to establish the effect of NOD on correlations between nasal and synonasal symptoms with clinical assessments of asthma control, 82 children, 9.8 [8.9; 10.7] years old, with atopic BA were assessed using ACQ-5 for the BA control level, TNSS for nasal symptoms, and SNOT-20 for synonasal quality of life in combination with rhinovideoendoscopy for NOD. All patients had AR/ARS; in 76.3% (63/82) of children, UAP had a multimorbid character with the presence of NOD. Significant correlations were found between ACQ-5 and TNSS (=0.40, < 0.0001) and ACQ-5 and SNOT-20 (=0.42, < 0.0001). Correlations between TNSS/ACQ-5 and SNOT-20/ACQ-5 were higher in patients who do not have a combination of AR/ARS with NOD (=0.67, =0.0012; =0.50, =0.022, resp.) than in patients who have AR/ARS combined with NOD (=0.30, =0.015; =0.26, =0.04, resp.). Thus, the association of BA control level with the expression of nasal and synonasal symptoms is higher in children who do not have multimorbid UAP.
变应性鼻炎（AR）和变应性鼻-鼻窦炎（ARS）是支气管哮喘（BA）患儿典型的上气道疾病（UAP），常伴有鼻阻塞性疾病（NOD）。为了确定NOD对鼻及鼻窦症状与哮喘控制临床评估之间相关性的影响，对82名9.8[8.9；10.7]岁的特应性BA患儿进行了评估，使用ACQ-5评估BA控制水平，TNSS评估鼻症状，SNOT-20评估鼻窦生活质量，并结合鼻视频内镜检查评估NOD。所有患者均患有AR/ARS；76.3%（63/82）的患儿UAP具有多种疾病并存的特征，伴有NOD。发现ACQ-5与TNSS之间存在显著相关性（=0.40，<0.0001），ACQ-5与SNOT-20之间也存在显著相关性（=0.42，<0.0001）。在未合并AR/ARS与NOD的患者中，TNSS/ACQ-5与SNOT-20/ACQ-5之间的相关性更高（分别为=0.67，=0.0012；=0.50，=0.022），高于合并AR/ARS与NOD的患者（分别为=0.30，=0.015；=0.26，=0.04）。因此，在没有多种疾病并存的UAP的儿童中，BA控制水平与鼻及鼻窦症状表达之间的关联更高。
