Department of Medical Biotechnology, Yeungnam University, Gyeongsan 712-749, Republic of Korea.
Research Institute of Protein Sensor, Yeungnam University, Gyeongsan 712-749, Republic of Korea.
Oxid Med Cell Longev. 2018 Apr 16;2018:4809525. doi: 10.1155/2018/4809525. eCollection 2018.
Policosanol has been reported to improve blood pressure, lipid profile, and HDL functionality via inhibition of cholesteryl ester transfer protein (CETP) both and in zebrafish and human models. However, there are limited reports and randomized, double-blinded trials on policosanol that could advocate the blood pressure-lowering effect in prehypertensive participants. Therefore, we performed , , and ex vivo experiments to provide more substantial and concrete data on the blood pressure-lowering effect of policosanol. Consumption of policosanol for 8 weeks enhanced plasma antioxidant activity. In the policosanol group, plasma total cholesterol (TC) and triglyceride (TG) levels were reduced up to 20% and 14%, respectively, and HDL-C level was elevated up to 1.3-fold compared to that at week 0. TG/HDL-C and cholesteryl ester transfer protein (CETP) activities were reduced up to 36% and 20%, respectively. Uptake of oxidized LDL in macrophages was reduced as oxidized species levels were reduced, and HDL-associated paraoxonase activities were enhanced by 60% compared to those at week 0. Encapsulation of policosanol into reconstituted HDL (PCO-rHDL) enhanced cholesterol efflux activity and insulin secretion capacity. In conclusion, consumption of policosanol for 8 weeks in healthy female subjects resulted in lowered blood pressure and CETP activity via elevation of HDL/apoA-I contents and enhancement of HDL functionalities, including cholesterol efflux and insulin secretion. These functional enhancements of HDL can contribute to the prevention of aging-related diseases, hypertension, and stroke.
多廿烷醇已被报道通过抑制胆固醇酯转移蛋白（CETP）改善血压、血脂谱和高密度脂蛋白（HDL）功能，无论是在斑马鱼和人类模型中。然而，关于多廿烷醇的报道和随机、双盲试验有限，无法证明其在高血压前期参与者中的降压作用。因此，我们进行了体内、体外和离体实验，为多廿烷醇的降压作用提供更实质性和具体的数据。多廿烷醇的消耗持续 8 周可增强血浆抗氧化活性。在多廿烷醇组中，血浆总胆固醇（TC）和甘油三酯（TG）水平分别降低了 20%和 14%，高密度脂蛋白胆固醇（HDL-C）水平升高了 1.3 倍，与 0 周时相比。TG/HDL-C 和胆固醇酯转移蛋白（CETP）活性分别降低了 36%和 20%。由于氧化物质水平降低，巨噬细胞中氧化 LDL 的摄取减少，HDL 相关的对氧磷酶活性增强了 60%。与 0 周相比，将多廿烷醇包封到重组高密度脂蛋白（PCO-rHDL）中增强了胆固醇外排活性和胰岛素分泌能力。总之，在健康女性中持续消耗 8 周多廿烷醇可通过升高 HDL/载脂蛋白 A-I 含量和增强 HDL 功能，包括胆固醇外排和胰岛素分泌，降低血压和 CETP 活性。这些 HDL 的功能增强可以有助于预防与年龄相关的疾病、高血压和中风。
