Artemisinin Reserch Center, China Academy of Chinese Medical Sciences, Beijing 100700, China.
Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China.
Molecules. 2018 May 31;23(6):1329. doi: 10.3390/molecules23061329.
Artemisinin, which has been isolated from L., is the most effective antimalarial drug and has saved millions of lives. In addition, artemisinin and its derivatives have anti-tumor, anti-parasitic, anti-fibrosis, and anti-arrhythmic properties, which enhances the demand for these compounds. Improving the content of artemisinin in is therefore becoming an increasing research interest, as the chemical synthesis of this metabolite is not viable. Ultraviolet B and C irradiation have been reported to improve the artemisinin content in , but they are harmful to plant growth and development. Therefore, we screened other light sources to examine if they could promote artemisinin content without affecting plant growth and development. We found that red and blue light could enhance artemisinin accumulation by promoting the expression of the genes that were involved in artemisinin biosynthesis, such as (ADS) and (CYP71AV1) genes. Thus, in addition to being the main light sources for photosynthesis, red and blue light play a key role in plant secondary metabolism, and optimizing the combination of these light might allow for the productionof artemisinin-rich .
青蒿素是从青蒿中分离得到的，是最有效的抗疟药物，已挽救了数百万人的生命。此外，青蒿素及其衍生物具有抗肿瘤、抗寄生虫、抗纤维化和抗心律失常等特性，这增加了对这些化合物的需求。因此，提高青蒿素在青蒿中的含量成为越来越多的研究热点，因为这种代谢物的化学合成是不可行的。据报道，紫外光 B 和 C 辐射可以提高青蒿中的青蒿素含量，但它们对植物的生长和发育有害。因此，我们筛选了其他光源，以检查它们是否可以在不影响植物生长和发育的情况下促进青蒿素含量的增加。我们发现，红光和蓝光可以通过促进参与青蒿素生物合成的基因（如 ADS 和 CYP71AV1 基因）的表达来增强青蒿素的积累。因此，除了作为光合作用的主要光源外，红光和蓝光在植物次生代谢中也起着关键作用，优化这些光的组合可能允许生产富含青蒿素的青蒿。
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