类二十烷酸信号在结直肠癌发生中的作用。
Eicosanoid signaling in carcinogenesis of colorectal cancer.
机构信息
College of Life Science, Northwest University, Xi'an, Shaanxi, China.
Department of Food Science, University of Massachusetts, Amherst, MA, USA.
出版信息
Cancer Metastasis Rev. 2018 Sep;37(2-3):257-267. doi: 10.1007/s10555-018-9739-8.
Abstract
Colorectal cancer (CRC) is the third most common cancer and the second leading cause of cancer-related death in the USA. It is of practical importance to identify novel therapeutic targets of CRC to develop new anti-cancer drugs and to discover novel biomarkers of CRC to develop new detection methods. Eicosanoids, which are metabolites of polyunsaturated fatty acids produced by cyclooxygenase (COX), lipoxygenase (LOX), and cytochrome P450 (CYP) enzymes, are important lipid-signaling molecules involved in the regulation of inflammation and tumorigenesis. Substantial studies have shown that the profiles of eicosanoids are deregulated in CRC, and the enzymes, metabolites, and receptors in the eicosanoid signaling cascade play critical roles in regulating colonic inflammation and colon tumorigenesis. In this review, we discuss the roles of the COX, LOX, and CYP pathways in the carcinogenesis of CRC.
摘要
结直肠癌（CRC）是美国第三大常见癌症，也是癌症相关死亡的第二大主要原因。鉴定 CRC 的新型治疗靶点以开发新的抗癌药物，以及发现 CRC 的新型生物标志物以开发新的检测方法具有实际意义。类二十烷酸是环氧化酶（COX）、脂氧合酶（LOX）和细胞色素 P450（CYP）酶产生的多不饱和脂肪酸的代谢产物，是参与炎症和肿瘤发生调节的重要脂质信号分子。大量研究表明，CRC 中的类二十烷酸谱失调，类二十烷酸信号级联中的酶、代谢物和受体在调节结肠炎症和结肠肿瘤发生中发挥关键作用。在这篇综述中，我们讨论了 COX、LOX 和 CYP 途径在 CRC 发生中的作用。
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本文引用的文献
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Clin Exp Gastroenterol. 2017 Jul 19;10:177-185. doi: 10.2147/CEG.S121841. eCollection 2017.
2
Cysteinyl leukotriene receptor 1 facilitates tumorigenesis in a mouse model of colitis-associated colon cancer.半胱氨酰白三烯受体1在结肠炎相关结肠癌小鼠模型中促进肿瘤发生。
Oncotarget. 2017 May 23;8(21):34773-34786. doi: 10.18632/oncotarget.16718.
3
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Cell Mol Life Sci. 2017 May;74(10):1907-1921. doi: 10.1007/s00018-016-2441-5. Epub 2016 Dec 24.
4
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BMC Cancer. 2016 Jul 7;16:425. doi: 10.1186/s12885-016-2466-z.
5
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6
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NCHS Data Brief. 2015 Nov(219):1-8.
8
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J Clin Oncol. 2015 Nov 1;33(31):3591-7. doi: 10.1200/JCO.2014.58.9952. Epub 2015 Aug 17.
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