从中国采集的滇紫菀中的雅槛蓝烷类化合物以及3β-酰氧基呋喃雅槛蓝-15,6-内酯的结构修正

Eremophilanes from Ligularia hookeri Collected in China and Structural Revision of 3β-Acyloxyfuranoeremophilan-15,6-olide.

作者信息

Saito Yoshinori, Shiosaki Yuko, Fujiwara Miho, Mihara Kanako, Nakamizo Hiromi, Otose Kanako, Okamoto Yasuko, Nakashima Katsuyuki, Hanai Ryo, Kuroda Chiaki, Gong Xun, Matsuo Yosuke, Tanaka Takashi, Tori Motoo

机构信息

Graduate School of Biomedical Sciences, Nagasaki University.

Faculty of Pharmaceutical Sciences, Tokushima Bunri University.

出版信息

Chem Pharm Bull (Tokyo). 2018;66(6):668-673. doi: 10.1248/cpb.c18-00191.

DOI:10.1248/cpb.c18-00191

PMID:29863069

Abstract

Chemical constituents of Ligularia hookeri (Asteraceae) collected in Yunnan and Sichuan Provinces in China were examined for the first time. Seven furanoeremophilanes, five of which were new, as well as known bisabolane- and eudesmane-type sesquiterpenoids, were isolated. Spectroscopic evidence indicates that the previously reported 3β-(2'-methylpropenoyloxy)furanoeremophilan-15,6β-olide should be revised to 3β-(2'-methylpropenoyloxy)furanoeremophilan-15,6α-olide.

摘要

首次对采自中国云南和四川省的滇西橐吾（菊科）的化学成分进行了研究。分离得到了7种呋喃雅槛蓝烷类化合物，其中5种为新化合物，以及已知的没药烷型和桉叶烷型倍半萜类化合物。光谱证据表明，先前报道的3β-(2'-甲基丙烯酰氧基)呋喃雅槛蓝烷-15,6β-内酯应修订为3β-(2'-甲基丙烯酰氧基)呋喃雅槛蓝烷-15,6α-内酯。