通过正交点击反应设计功能化环肽用于细胞培养和靶向应用。
Design of functionalized cyclic peptides through orthogonal click reactions for cell culture and targeting applications.
机构信息
Department of Chemical and Biomolecular Engineering, University of Delaware, Newark, DE 19716, USA.
出版信息
Chem Commun (Camb). 2018 Jun 19;54(50):6923-6926. doi: 10.1039/c8cc03218a.
Abstract
An approach for the design of functionalized cyclic peptides is established for use in 3D cell culture and in cell targeting. Sequential orthogonal click reactions, specifically a photoinitiated thiol-ene and strain promoted azide-alkyne cycloaddition, were utilized for peptide cyclization and conjugation relevant for biomaterial and biomedical applications, respectively.
摘要
建立了一种用于 3D 细胞培养和细胞靶向的功能化环肽设计方法。分别利用顺序正交点击反应，即光引发的硫醇-烯反应和应变促进的叠氮-炔环加成反应，用于肽环化和共轭，分别与生物材料和生物医学应用相关。
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