Dancyger Alex, Heard Victoria, Huang Baikai, Suley Cameron, Tang Dorothy, Ariyawardana Anura
College of Medicine and Dentistry, James Cook University, Cairns, Queensland, Australia.
J Investig Clin Dent. 2018 Nov;9(4):e12343. doi: 10.1111/jicd.12343. Epub 2018 Jun 4.
The aim of the present systematic review was to determine the malignant transformation rate of actinic cheilitis (AC). A comprehensive literature search was conducted using Medline/PubMed, Cumulative Index of Nursing and Allied Health Literature, Scopus, OvidSP, and Google Scholar. The inclusion criteria comprised of observational human studies involving the malignant transformation of AC and publications in English. Studies included in this review were clinical follow-up, cohort, retrospective, or prospective investigations. The search yielded 1126 articles, and after exclusion, 34 full-text articles were eligible for full-text analysis. Only one article met the inclusion criteria. Based on the included article, it was determined that the malignant transformation rate of AC to squamous cell carcinoma (SCC) was 3.07%. Excluded articles focused on the clinicopathological characteristics and treatment efficacies of AC, and no malignant transformation rate was assessed. There is a need for more clinical studies on the malignant transformation of AC, as lip cancer is a public health concern. High-risk populations, including those living in tropical regions, have excessive exposure to UV radiation, and have older aged males, fair-skinned people, and smokers should be identified to prevent AC and its malignant change. Health practitioners should facilitate early intervention to prevent the progression of AC to SCC of the lip.
本系统评价的目的是确定光化性唇炎（AC）的恶变率。通过Medline/PubMed、护理及相关健康文献累积索引、Scopus、OvidSP和谷歌学术进行了全面的文献检索。纳入标准包括涉及AC恶变的观察性人体研究以及英文出版物。本评价纳入的研究包括临床随访、队列、回顾性或前瞻性调查。检索共得到1126篇文章，排除后，有34篇全文文章符合全文分析的条件。只有一篇文章符合纳入标准。根据纳入的文章，确定AC恶变为鳞状细胞癌（SCC）的恶变率为3.07%。排除的文章聚焦于AC的临床病理特征和治疗效果，未评估恶变率。由于唇癌是一个公共卫生问题，因此需要对AC的恶变进行更多的临床研究。应识别高危人群，包括生活在热带地区、过度暴露于紫外线辐射、老年男性、皮肤白皙者和吸烟者，以预防AC及其恶变。医疗从业者应促进早期干预，以防止AC进展为唇部SCC。
