Ge Song, Sanchez Michael, Nolan Marie, Liu Tingting, Savage Christine L
Song Ge, PhD, RN, BSN, Michael Sanchez, DNP, CRNP, FNP-BC, Marie Nolan, PhD, MPH, RN, FAAN, and Christine L. Savage, PhD, RN, CARN, FAAN, School of Nursing, Johns Hopkins University, Baltimore, Maryland. Tingting Liu, PhD, RN, Eleanor Mann School of Nursing, University of Arkansas, Fayetteville, Arkansas.
J Addict Nurs. 2018 Apr/Jun;29(2):96-118. doi: 10.1097/JAN.0000000000000220.
Alcohol use is associated with many HIV-related behaviors that are associated with increased risk of reinfection, transmission, and poorer health outcomes in people living with HIV (PLHIV). The population of middle-aged and older PLHIV is growing because of increased life longevity and aging trend.
A systematic review across three databases was conducted to evaluate existing studies that examined the association between alcohol use and medication adherence, high-risk sex behaviors, HIV progression, depression, resource utilization, and survival among studies of PLHIV with an average age of 40 years and above.
Among the 47 included studies, most found a positive association between alcohol use and depression, risky sex behaviors, medication nonadherence, and healthcare resource utilization among PLHIV. The association between alcohol use and response to treatment was variable. The association between alcohol use and survival warrants further study because of lack of existing studies.
The results of this review support that alcohol use negatively impacts middle-aged and older PLHIV in many aspects; however, there is lack of studies exclusively targeting older PLHIV, and more relevant studies in the future are needed.
饮酒与许多与艾滋病病毒（HIV）相关的行为有关，这些行为会增加HIV感染者（PLHIV）再次感染、传播的风险，并导致更差的健康结果。由于寿命延长和老龄化趋势，中年及老年PLHIV人群正在增加。
对三个数据库进行系统综述，以评估现有研究，这些研究考察了平均年龄40岁及以上的PLHIV研究中饮酒与药物依从性、高危性行为、HIV进展、抑郁、资源利用和生存之间的关联。
在纳入的47项研究中，大多数研究发现饮酒与PLHIV中的抑郁、危险行为、药物不依从和医疗资源利用之间存在正相关。饮酒与治疗反应之间的关联各不相同。由于现有研究不足，饮酒与生存之间的关联值得进一步研究。
本综述结果支持饮酒在许多方面对中年及老年PLHIV产生负面影响；然而，缺乏专门针对老年PLHIV的研究，未来需要更多相关研究。
