铋盐对轮状病毒及其他肠道病毒的体外活性。
In vitro activities of bismuth salts against rotaviruses and other enteric viruses.
作者信息
Ward R L, Sander D S, Knowlton D R
出版信息
Antimicrob Agents Chemother. 1985 Mar;27(3):306-8. doi: 10.1128/AAC.27.3.306.
Abstract
Bismuth salts inhibited plaque formation of all enteric viruses tested, which included four strains of rotavirus and one strain each of echovirus, reovirus, and poliovirus. The compounds had no direct virucidal effect at concentrations ranging from 0.025 to 2.5 mg/ml, and the inhibitory effects were observed only at concentrations slightly below those that caused extensive cytotoxicity. Plaque inhibition appeared to result from interference with host cell functions, with secondary inhibition of virus production.
摘要
铋盐抑制了所有测试肠道病毒的噬斑形成，其中包括四株轮状病毒以及各一株艾柯病毒、呼肠孤病毒和脊髓灰质炎病毒。在浓度范围为0.025至2.5毫克/毫升时，这些化合物没有直接的杀病毒作用，仅在略低于引起广泛细胞毒性的浓度时才观察到抑制作用。噬斑抑制似乎是由于干扰宿主细胞功能，继而抑制病毒产生所致。
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