The Glucose-Regulated Influences Key Signaling Pathways in Cancer.

The gene, located within the locus, transcribes for two mature microRNAs, and . This gene, whose regulation is mediated by the the CTNNB1/USF1 complex, shows an independent expression from its host gene . The affects the Wnt/β-catenin, the TGF-β, and the TP53 signaling pathways by targeting several genes as , , , and . Accordingly, is associated with various tissues specific physiological properties as insulin and melanin production, as well as with cellular physiological functions such as wounding, differentiation, proliferation, and survival. Deregulation of is observed in different types of cancer, and its overexpression can inhibit the pro-apoptotic pathway induced by the TP53 target effectors. As a result, the oncogenic characteristics of are linked to the effect of some of the most relevant cancer-related genes, and , as well as to one of the most important cancer hallmark: the aberrant glucose metabolism of tumor cells. In this review, we summarize the recent findings regarding the , to elucidate its functional role in physiological and pathological contexts, focusing overall on its involvement in cancer and in the TP53 pathway.