Zhang Yong, Liu Yan, Qiu Jiazhang, Luo Zhao-Qing, Deng Xuming
Key Laboratory of Zoonosis, Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine, Jilin University, Changchun, China.
Center of Infection and Immunity, The First Hospital, Jilin University, Changchun, China.
Front Microbiol. 2018 May 16;9:1022. doi: 10.3389/fmicb.2018.01022. eCollection 2018.
Type III secretion system (T3SS) is an essential pathogenic determinant for many important bacterial pathogens; it functions to thwart immune defense by delivering effectors into host cells. Because of its essential role in bacterial virulence, this machinery is an important target in the development of novel anti-virulence therapeutics. By using an effector-lactamase fusion reporter, we identified thymol, a monoterpene phenol derivative of cymene, as an effective inhibitor of the T3SS-1 of Typhimurium. Our results indicate that thymol effectively protected mice against . Typhimurium-induced mortality and pathological damages, suggesting that this compound can be developed for the control of infections caused by species.
III型分泌系统（T3SS）是许多重要细菌病原体的关键致病决定因素；它通过将效应蛋白输送到宿主细胞中来挫败免疫防御。由于其在细菌毒力中的关键作用，这种机制是新型抗毒力疗法开发的重要靶点。通过使用效应蛋白-内酰胺酶融合报告基因，我们鉴定出百里香酚，一种伞花烃的单萜酚衍生物，作为鼠伤寒沙门氏菌T3SS-1的有效抑制剂。我们的结果表明，百里香酚有效地保护小鼠免受鼠伤寒沙门氏菌诱导的死亡和病理损伤，表明这种化合物可用于控制由该菌种引起的感染。
