Laboratory of Social Psychology, Department of Ergonomics, Central Institute for Labour Protection - National Research Institute, 16 Czerniakowska Street, 00-701, Warsaw, Poland.
Laboratory of Psychophysiology, Department of Neurophysiology, Nencki Institute of Experimental Biology, Polish Academy of Sciences, 3 Pasteur Street, 02-093, Warsaw, Poland.
J Autism Dev Disord. 2019 Mar;49(3):1267-1277. doi: 10.1007/s10803-018-3621-y.
Previous studies indicate that autobiographical memory is impaired in individuals with autism spectrum disorder (ASD). Successful recollection of information referring to one's own person requires the intact ability to re-activate representation of the past self. In the current fMRI study we investigated process of conscious reflection on the present self, the past self, and a close-other in the ASD and typically developing groups. Significant inter-group differences were found in the Past-Self condition. In individuals with ASD, reflection on the past self was associated with additional engagement of the posterior cingulate and posterior temporal structures. We hypothesize that this enhanced activation of widely distributed neural network reflects substantial difficulties in processes of reflection on one's own person in the past.
先前的研究表明，自闭症谱系障碍（ASD）患者的自传体记忆受损。成功回忆与自己有关的信息需要能够完整地重新激活过去自我的表象。在当前的 fMRI 研究中，我们在 ASD 和典型发育组中调查了对当前自我、过去自我和亲密他人的有意识反思过程。在过去自我条件下，发现了组间的显著差异。在 ASD 个体中，对过去自我的反思与后扣带回和后颞叶结构的额外参与有关。我们假设，这种广泛分布的神经网络的增强激活反映了过去对自身进行反思的过程中存在的实质性困难。
