肺与食管：发育与再生的重叠。

Division of Cardiovascular Medicine, Center for Pulmonary Biology, Cardiovascular Institute, Institute for Regenerative Medicine, Abramson Cancer Center, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA 19104, USA.

Division of Gastroenterology, Departments of Medicine and Genetics, Institute for Regenerative Medicine, Abramson Cancer Center, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA 19104, USA.

Trends Cell Biol. 2018 Sep;28(9):738-748. doi: 10.1016/j.tcb.2018.04.007. Epub 2018 Jun 2.

Lung and esophageal development and organogenesis involve a complex interplay of signaling pathways and transcriptional factors. Once the lung and esophagus do separate, their epithelial proliferation and differentiation programs share certain common properties that may fuel adaptive responses to injury and subsequent regeneration. Lung and esophageal tissue organogenesis and regeneration provide perspectives on squamous cell cancers and adenocarcinomas in each tissue.

肺和食管的发育和器官发生涉及信号通路和转录因子的复杂相互作用。一旦肺和食管分开，它们的上皮细胞增殖和分化程序就具有某些共同的特性，这些特性可能为损伤后的适应性反应和随后的再生提供动力。肺和食管组织的发生和再生为这两种组织中的鳞状细胞癌和腺癌提供了新的视角。