Londono Ricardo, Badylak Stephen F
1 McGowan Institute for Regenerative Medicine, University of Pittsburgh , Pittsburgh, Pennsylvania.
2 School of Medicine, University of Pittsburgh , Pittsburgh, Pennsylvania.
Tissue Eng Part B Rev. 2015 Aug;21(4):393-410. doi: 10.1089/ten.TEB.2015.0014. Epub 2015 Apr 30.
Pathologies that involve the structure and/or function of the esophagus can be life-threatening. The esophagus is a complex organ comprising nonredundant tissue that does not have the ability to regenerate. Currently available interventions for esophageal pathology have limited success and are typically associated with significant morbidity. Hence, there is currently an unmet clinical need for effective methods of esophageal repair. The present article presents a review of esophageal disease along with the anatomic and functional consequences of each pathologic process, the shortcomings associated with currently available therapies, and the latest advancements in the field of regenerative medicine with respect to strategies for esophageal repair from benchtop to bedside.
涉及食管结构和/或功能的病理状况可能危及生命。食管是一个复杂的器官，由无冗余组织构成，没有再生能力。目前针对食管病理状况的现有干预措施成功率有限，且通常伴有严重的发病率。因此，目前临床上对有效的食管修复方法存在未满足的需求。本文综述了食管疾病，以及每个病理过程的解剖和功能后果、现有疗法的缺点，以及再生医学领域从实验室到临床的食管修复策略的最新进展。
