Department of Pathophysiology, Iuliu Haţieganu University of Medicine and Pharmacy Cluj-Napoca, Cluj-Napoca, Romania.
Department of Medical Informatics and Biostatistics, Iuliu Haţieganu University of Medicine and Pharmacy Cluj-Napoca, Cluj-Napoca, Romania.
Int J Nanomedicine. 2018 May 25;13:3093-3103. doi: 10.2147/IJN.S162087. eCollection 2018.
Curcumin has antioxidative properties that could be useful in various diseases due to its ability to act on multiple targets of various cellular pathways. We aimed to assess the efficacy of liposomal curcumin compared with curcumin solution, when in addition to sumatriptan (ST) treatment, in an experimental migraine model induced with nitroglycerin (NTG) in rats.
Seven groups of 9 rats each were investigated: control group without migraine (1 mL saline solution intraperitoneal injection [ip]), control group with induced migraine, NTG+ST group (ST), NTG+ST+curcumin1 (CC1) group - 1 mg/100 g body weight (bw), NTG+ST+CC2 - 2 mg/100 g bw, NTG+ST+liposomal curcumin1 (lCC1) group - 1 mg/100 g bw, and NTG+ST+lCC2 (lCC2) group - 2 mg/100 g bw. NTG and ST were administered as 1 mL ip NTG | 1 mg/100 g bw and 1 mL ip ST | 1 mg/100 g bw, respectively. Plasma total oxidative stress (TOS), malondialdehyde (MDA), nitric oxide (NOx), thiol levels, as well as total antioxidative capacity (TAC) were assessed. The nociception process was assessed by counting the number of flinches and shakes after the formalin test.
The plasma TOS, MDA, and NOx levels, as oxidative stress parameters, were significantly decreased in the curcumin-treated groups, especially where curcumin was in liposomal form. The thiol and TAC were also improved by the curcumin treatment, with the best results obtained for the liposomal curcumin. The closest number of flinches and shakes to the control group was obtained for the group treated with liposomal curcumin at a dose of 2 mg/100 g bw.
Liposomal curcumin in a dose of 2 mg/100 g bw when in addition to ST treatment could be an optimum therapeutic strategy for migraine attacks and could represent a base for future clinical research and application.
姜黄素具有抗氧化特性，由于其能够作用于多种细胞通路的多个靶点，因此在各种疾病中可能具有应用价值。我们旨在评估脂质体姜黄素与姜黄素溶液相比的疗效，当它与舒马曲坦（ST）治疗联合使用时，在大鼠中用硝化甘油（NTG）诱导的实验性偏头痛模型中。
我们研究了 7 组每组 9 只大鼠：无偏头痛的对照组（腹腔注射 1 毫升生理盐水溶液 [ip]）、诱导偏头痛的对照组、NTG+ST 组（ST）、NTG+ST+CC1 组 - 1mg/100g 体重（bw）、NTG+ST+CC2-2mg/100g bw、NTG+ST+脂质体姜黄素 1 组（lCC1）-1mg/100g bw 和 NTG+ST+lCC2（lCC2）组 - 2mg/100g bw。NTG 和 ST 分别以 1ml ip NTG | 1mg/100g bw 和 1ml ip ST | 1mg/100g bw 的剂量给予。评估血浆总氧化应激（TOS）、丙二醛（MDA）、一氧化氮（NOx）、巯基水平以及总抗氧化能力（TAC）。通过计算福尔马林试验后抽搐和颤抖的次数来评估疼痛过程。
作为氧化应激参数的血浆 TOS、MDA 和 NOx 水平在姜黄素治疗组中显著降低，尤其是以脂质体形式存在的姜黄素。巯基和 TAC 也因姜黄素治疗而得到改善，其中以脂质体姜黄素的效果最佳。在剂量为 2mg/100g bw 的脂质体姜黄素治疗组中，抽搐和颤抖的次数最接近对照组。
当与 ST 治疗联合使用时，剂量为 2mg/100g bw 的脂质体姜黄素可能是偏头痛发作的最佳治疗策略，并可能为未来的临床研究和应用提供基础。
