Department of Sport Physiology, Tarbiat Modares University, Tehran, Iran.
Department of Physical Therapy, University of Alabama at Birmingham, Birmingham, AL, USA.
Neuropeptides. 2018 Aug;70:93-100. doi: 10.1016/j.npep.2018.05.010. Epub 2018 May 31.
Blood-brain barrier (BBB) and neurotrophic factors seemingly have an important role in multiple sclerosis pathology. Physical activity may influence blood-brain barrier function and levels of neurotrophic factors, and such effects might be moderated by body weight status. This study investigated the effect of exercise training on markers of blood-brain barrier permeability and neurotrophic factors as a function of weight status in multiple sclerosis patients. Sixty three persons with relapsing remitting multiple sclerosis who were normal weight (n: 33) or overweight (n: 33) were randomly assigned into groups of exercise (normal weight training, n: 18; overweight training group, n: 18) or no exercise (normal weight control, n: 15; overweight control group, n: 15). The intervention consisted of 8 weeks (3 days per week) of cycling undertaken at 60-70% peak power. Resting blood concentrations of s100 calcium-binding protein B (s100b) and neuron-specific enolase as BBB permeability markers, neurotrophic factors and cytokines (Interleukin-10 and tumor necrosis factor alpha) were evaluated before and after the intervention. There were significant weight, training, and interaction effects on brain-derived neurotrophic factor and platelet-derived growth factor; however, ciliary neurotrophic factor and nerve growth factor did not demonstrate any effect. Brain-derived neurotrophic factor and platelet-derived growth factor were significantly increased from pre-post in normal weight exercise. Significant weight, training, and interaction effects were found for s100b. In detail, s100b was significantly increased from pre-post in normal weight exercise. In contrast, neuron-specific enolase and cytokines did not demonstrate any effect. Generally, Exercise training may alter markers of BBB permeability and neurotrophic factor status in normal weight persons with multiple sclerosis; however, overweight participants may be more resistant to these effects of exercise.
血脑屏障（BBB）和神经营养因子似乎在多发性硬化症的病理中起着重要作用。身体活动可能会影响血脑屏障的功能和神经营养因子的水平，而这种影响可能受到体重状况的调节。本研究调查了运动训练对多发性硬化症患者血脑屏障通透性标志物和神经营养因子的影响，以及体重状况对这些影响的调节作用。63 名复发缓解型多发性硬化症患者，体重正常（n=33）或超重（n=33），随机分为运动组（正常体重训练组，n=18；超重训练组，n=18）或不运动组（正常体重对照组，n=15；超重对照组，n=15）。干预措施包括 8 周（每周 3 天）的自行车运动，强度为 60-70%的峰值功率。在干预前后，评估了静止状态下血脑屏障通透性标志物 s100 钙结合蛋白 B（s100b）和神经元特异性烯醇化酶、神经营养因子和细胞因子（白细胞介素 10 和肿瘤坏死因子-α）的浓度。体重、训练和交互作用对脑源性神经营养因子和血小板源性生长因子有显著影响；然而，睫状神经营养因子和神经生长因子没有显示出任何影响。脑源性神经营养因子和血小板源性生长因子在正常体重运动组的前后测量中显著增加。在正常体重运动组中，s100b 也显示出显著的体重、训练和交互作用。具体来说，s100b 在正常体重运动组的前后测量中显著增加。相比之下，神经元特异性烯醇化酶和细胞因子没有显示出任何影响。总的来说，运动训练可能会改变正常体重多发性硬化症患者血脑屏障通透性标志物和神经营养因子状态；然而，超重参与者可能对运动的这些影响更有抵抗力。
