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骆驼奶对糖尿病有有益影响:一项系统综述。

Camel Milk Has Beneficial Effects on Diabetes Mellitus: A Systematic Review.

作者信息

Mirmiran Parvin, Ejtahed Hanieh-Sadat, Angoorani Pooneh, Eslami Fariba, Azizi Fereidoun

机构信息

Nutrition and Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran.

Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran.

出版信息

Int J Endocrinol Metab. 2017 Mar 11;15(2):e42150. doi: 10.5812/ijem.42150. eCollection 2017 Apr.

Abstract

CONTEXT

Controlling diabetes, a worldwide metabolic disease, by effective alternative treatments is currently a topic of great interest. Camel milk is believed to be a suitable hypoglycemic agent in experimental animals and patients with diabetes. The current systematic review aimed at evaluating the effect of camel milk on diabetes.

EVIDENCE ACQUISITION

A comprehensive search was dine in PubMed and Scopus for all clinical trials and animal studies documented up to 2015, which focused on the effect of camel milk on diabetes markers. Studies which assessed the effects of camel milk, with no dose limit, on glucose parameters and lipid profiles in animals or humans with diabetes, were included. The quality of the included clinical trials was evaluated by the Delphi score checklist.

RESULTS

The initial search yielded 73 articles. After screening abstracts and full texts, 22 articles were included consisting of 11 animal studies and 11 clinical trials, 8 of which focused on type 1 diabetes and the other three on type 2diabetes. All animal studies except for 1 showed significant reductions in at least 1 of the diabetes parameters such as blood glucose, insulin resistance, glycated hemoglobin, and lipid profile. In most of the clinical trials, the recommended dose of camel milk was 500 mL/day, which led to improvement of diabetes markers even after 3 months in patients with diabetes.

CONCLUSIONS

Most of the studies in the current systematic review demonstrated the favorable effects of camel milk on diabetes mellitus by reducing blood sugar, decreasing insulin resistance and improving lipid profiles.

摘要

背景

通过有效的替代疗法控制糖尿病这一全球性代谢疾病,是当前备受关注的话题。骆驼奶被认为是实验动物和糖尿病患者适宜的降血糖剂。本系统评价旨在评估骆驼奶对糖尿病的影响。

证据获取

在PubMed和Scopus中全面检索截至2015年记录的所有临床试验和动物研究,这些研究聚焦于骆驼奶对糖尿病标志物的影响。纳入评估骆驼奶对糖尿病动物或人类的血糖参数和血脂谱影响的研究,不限剂量。采用德尔菲评分清单评估纳入临床试验的质量。

结果

初步检索得到73篇文章。经摘要和全文筛选,纳入22篇文章,包括11项动物研究和11项临床试验,其中8项聚焦1型糖尿病,另外3项聚焦2型糖尿病。除1项外,所有动物研究均显示至少1项糖尿病参数如血糖、胰岛素抵抗、糖化血红蛋白和血脂谱有显著降低。在大多数临床试验中,骆驼奶的推荐剂量为500毫升/天,即使在糖尿病患者中3个月后也能使糖尿病标志物得到改善。

结论

当前系统评价中的大多数研究表明,骆驼奶通过降低血糖、减少胰岛素抵抗和改善血脂谱对糖尿病有有益作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a52e/5626114/a23ad423463b/ijem-15-02-42150-i001.jpg

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