DiGiacomo Kristy, Zamuner Fernanda, Sun Yushu, Dunshea Frank R, Raynes Jared K, Leury Brian J
Faculty of Veterinary and Agricultural Sciences, School of Agriculture and Food, University of Melbourne, Parkville, VIC 2010, Australia.
Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, UK.
Animals (Basel). 2022 Jun 30;12(13):1701. doi: 10.3390/ani12131701.
Evidence suggests that camel milk (CM) can have insulin-like actions, although the mode of action is not understood. Using the pig as a monogastric model, this pilot experiment examined the effects of CM consumption on metabolic responses to an in vitro glucose tolerance test (IVGTT). Twenty female Large White × Landrace pigs were individually housed for 6 wks and randomly allocated to one of the following four diets (fed ad libitum; = 5): control (Con); high fat (HF; ~16% fat); raw CM (the HF diet plus 500 mL CM/ day); or pasteurized CM (PCM). Blood samples were collected on two occasions (weeks 2 and 5). At week 6, the pigs were fitted with an ear vein cannula and the following day an in vitro glucose tolerance test (IVGTT) was conducted (0.3 g/kg BW glucose). Plasma fatty acids and cholesterol concentrations were greater in the pigs fed the HF diet and greatest in those fed CM, while there was no effect of diet on insulin concentrations. The pigs fed CM tended to have a reduced peak insulin ( = 0.058) and an increased glucose nadir ( = 0.009) in response to the IVGTT. These preliminary results tend to support the hypothesis that feeding CM can improve glycemic control in pigs.
有证据表明骆驼奶（CM）可能具有类似胰岛素的作用，尽管其作用方式尚不清楚。本试验以猪作为单胃动物模型，研究了饮用骆驼奶对体外葡萄糖耐量试验（IVGTT）代谢反应的影响。20头雌性大白×长白猪单独饲养6周，并随机分配到以下四种日粮之一（自由采食；每组n = 5）：对照组（Con）；高脂组（HF；脂肪含量约16%）；生骆驼奶组（高脂日粮加500毫升/天骆驼奶）；或巴氏杀菌骆驼奶组（PCM）。在两个时间点（第2周和第5周）采集血样。第6周时，给猪安装耳静脉插管，第二天进行体外葡萄糖耐量试验（0.3克/千克体重葡萄糖）。高脂日粮组猪的血浆脂肪酸和胆固醇浓度更高，而饮用骆驼奶组猪的这些指标最高，日粮对胰岛素浓度没有影响。饮用骆驼奶的猪在IVGTT后胰岛素峰值有降低趋势（P = 0.058），葡萄糖最低点有升高趋势（P = 0.009）。这些初步结果倾向于支持饮用骆驼奶可改善猪血糖控制的假说。
