Department of Dermatology, University Hospitals KU Leuven, Leuven, Belgium.
Contact Dermatitis. 2018 Aug;79(2):81-84. doi: 10.1111/cod.13044. Epub 2018 Jun 11.
Acrylates and methacrylates are acrylic resin monomers that are known to induce skin sensitization as a result of their presence in different materials, such as nail cosmetics, dental materials, printing inks, and adhesives. Allergic contact dermatitis resulting from the use of modern wound dressings containing them has only rarely been reported.
To describe 2 patients who developed allergic contact dermatitis caused by acrylic-based modern medical dressings and/or adhesives.
The medical charts of patients consulting since 1990 were retrospectively reviewed for (meth)acrylate allergy resulting from contact with such materials, and their demographic characteristics and patch test results were analysed.
Two patients were observed in 2014 and 2016 who had presented with positive patch test reactions to several acrylic-based dressings and/or adhesive materials, and to several (meth)acrylates, that is, hydroxyethyl acrylate, hydroxyethyl methacrylate, ethyleneglycol dimethacrylate, bisphenol A-glycidyl methacrylate/epoxy-acrylate, urethane diacrylate, and/or penta-erythritol acrylate.
Allergic contact dermatitis needs to be considered in patients with eczematous reactions or delayed healing following the use of acrylic-based modern dressings or adhesives. However, identification of the culprit allergen is hampered by poor cooperation from the producers, so adequate labelling of medical devices is an urgent necessity.
丙烯酸酯和甲基丙烯酸酯是丙烯酸树脂单体,由于它们存在于不同的材料中,如指甲油、牙科材料、印刷油墨和粘合剂,已知会引起皮肤致敏。由于使用含有它们的现代伤口敷料而导致的过敏性接触性皮炎仅很少有报道。
描述 2 例因使用含丙烯酸酯的现代医用敷料和/或粘合剂而发生过敏性接触性皮炎的患者。
回顾性查阅 1990 年以来就诊的患者病历,分析其因接触此类材料而发生(甲基)丙烯酸酯过敏的情况,分析其人口统计学特征和斑贴试验结果。
2014 年和 2016 年观察到 2 例患者,他们对几种含丙烯酸酯的敷料和/或粘合剂材料以及几种(甲基)丙烯酸酯(即羟乙基丙烯酸酯、羟乙基甲基丙烯酸酯、乙二醇二甲基丙烯酸酯、双酚 A-缩水甘油甲基丙烯酸酯/环氧丙烯酸酯、聚氨酯二丙烯酸酯和/或季戊四醇丙烯酸酯)的斑贴试验呈阳性反应。
对于使用含丙烯酸酯的现代敷料或粘合剂后出现湿疹样反应或愈合延迟的患者,需要考虑过敏性接触性皮炎。然而,由于生产商的配合不佳,过敏原的鉴定受到阻碍,因此迫切需要对医疗器械进行充分标记。