Finnish Institute of Occupational Health (FIOH), Occupational Health Unit, Helsinki, Finland.
Contact Dermatitis. 2021 Apr;84(4):240-246. doi: 10.1111/cod.13739. Epub 2020 Dec 1.
Contact allergy from acrylic compounds is a "hot topic". Knowledge on the exact chemical composition of acrylic products is superficial.
To retrospectively describe patients with allergic reactions to acrylic compounds.
We included patients who had been tested with acrylate patch test series and displayed allergic reactions to at least one acrylic compound. Chemical analyses were often performed when safety data sheets of implicated products failed to reveal acrylic compounds to which the patient tested positive.
In 2010-2019 a total of 55 patients met the inclusion criteria. Eight cases of allergic contact dermatitis were due to anaerobic sealants, seven to dental products, three to windscreen glues, seven to eyelash glues and/or nail products in the beauty sector, three to UV-cured printing inks, two to paints/lacquers, and one to polyester resin system. The origin of these contact allergies was occupational with the exception of four beauty sector workers who had developed eyelid symptoms from eyelash extensions glued onto their own eyelashes. We invariably detected methacrylate monomers in 15 chemical analyses of 12 different anaerobic sealants.
Safety data sheets of anaerobic sealants often lack warnings for skin sensitization, although these products regularly contain sensitizing methacrylates.
丙烯酸化合物引起的接触过敏是一个“热门话题”。对丙烯酸产品的确切化学成分的了解还很肤浅。
回顾性描述对丙烯酸化合物过敏的患者。
我们纳入了接受丙烯酸盐斑贴试验系列检测且至少对一种丙烯酸化合物呈过敏反应的患者。当可疑产品的安全数据表未能显示患者呈阳性的丙烯酸化合物时，通常会进行化学分析。
在 2010 年至 2019 年间，共有 55 名患者符合纳入标准。8 例过敏性接触性皮炎是由厌氧密封剂引起的，7 例是由牙科产品引起的，3 例是由挡风玻璃胶引起的，7 例是由睫毛胶和/或美容行业的指甲产品引起的，3 例是由紫外线固化印刷油墨引起的，2 例是由油漆/清漆引起的，1 例是由聚酯树脂系统引起的。这些接触过敏的来源是职业性的，除了 4 名美容行业的工人因将睫毛胶粘贴在自己的睫毛上而出现眼睑症状外。我们在对 12 种不同的厌氧密封剂的 15 次化学分析中都检测到了甲基丙烯酸单体。
厌氧密封剂的安全数据表经常缺乏对皮肤致敏的警告，尽管这些产品经常含有致敏性的甲基丙烯酸酯。
