偏头痛患者γ-氨基丁酸及以上物质的高场磁共振波谱研究：对左乙拉西坦治疗的反应
High-field MRS study of GABA+ in patients with migraine: response to levetiracetam treatment.
作者信息
Li Qiang, Chen Chunfu, Gong Tao
机构信息
Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong University.
Department of Neurology, Shandong Provincial Third Hospital.
出版信息
Neuroreport. 2018 Aug 15;29(12):1007-1010. doi: 10.1097/WNR.0000000000001067.
To explore alterations in γ-aminobutyric acid (GABA) levels in response to levetiracetam (LEV) treatment in patients with migraine. Patients with migraine (N=14) were treated with LEV for 12 weeks. The levels of GABA+ in the anterior cingulate cortex/medial prefrontal cortex (ACC/mPFC) and the posterior cingulate cortex (PCC) were examined by proton magnetic resonance spectroscopy before (baseline) and after treatment. LEV showed good efficacy in the reduction of headache frequency and intensity in patients with migraine. Among the 14 patients, good-quality spectral data of GABA+ in the PCC region were obtained in 11 patients. There was a significant decrease in GABA+ levels in the PCC region after LEV treatment. ACC/mPFC GABA+ was assessed by proton magnetic resonance spectroscopy in eight patients with migraine. LEV had no significant effect on GABA+ levels in the ACC/mPFC region. The decreased GABA+ levels after LEV treatment in patients with migraine suggest that GABA is a migraine biomarker.
探讨偏头痛患者接受左乙拉西坦（LEV）治疗后γ-氨基丁酸（GABA）水平的变化。14例偏头痛患者接受LEV治疗12周。在治疗前（基线）和治疗后，通过质子磁共振波谱检查前扣带回皮质/内侧前额叶皮质（ACC/mPFC）和后扣带回皮质（PCC）中GABA+的水平。LEV在降低偏头痛患者的头痛频率和强度方面显示出良好疗效。14例患者中，11例获得了PCC区域GABA+的高质量光谱数据。LEV治疗后PCC区域GABA+水平显著降低。对8例偏头痛患者通过质子磁共振波谱评估ACC/mPFC中的GABA+。LEV对ACC/mPFC区域的GABA+水平无显著影响。偏头痛患者接受LEV治疗后GABA+水平降低表明GABA是一种偏头痛生物标志物。
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