Department of Basic Veterinary, College of Veterinary Medicine, Sichuan Agricultural University, Wenjiang District, Huimin Road No. 211, Chengdu 611130, Sichuan, PR China; Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Wenjiang District, Huimin Road No.211, Chengdu 611130, Sichuan, PR China.
Department of Basic Veterinary, College of Veterinary Medicine, Sichuan Agricultural University, Wenjiang District, Huimin Road No. 211, Chengdu 611130, Sichuan, PR China; Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Wenjiang District, Huimin Road No.211, Chengdu 611130, Sichuan, PR China.
Ecotoxicol Environ Saf. 2018 Oct;161:342-349. doi: 10.1016/j.ecoenv.2018.05.079. Epub 2018 Jun 8.
Olaquindox, is a growth-promoting feed additive for food-producing animals. As the banned medicinal feed additive, olaquindox in animal feed and water must be concerned as an important hazard index. To improve studies of the toxicity of olaquindox, we provide a toxicological effects of olaquindox on a common freshwater fish, Cyprinus carpio L. The results of acute toxicity tests showed that the 7d-LD of olaquindox administered by feeding for common carp was determined to be 3746.3 mg/kg. We also found that the accumulation coefficient of olaquindox in carp was 1.45-1.9. Based on the studied hematological and blood biochemical parameters (RBCs count, hemoglobin content, ALT, AST and SOD activity), we found that olaquindox induced significant alterations in all studied parameters. Regarding bioaccumulation, the results showed that olaquindox had more efficiency to internalize fish tissues (liver, kidneys and muscle). The histopathological investigation of tissues from poisoning fish revealed various alterations that varied between adaptation responses and permanent tissue damage. Our results indicate that olaquindox are toxic to common carp and have obvious accumulation, and all the data from acute and subacute toxicity experiments in common carp may provide a useful tool for assessing the toxicity of olaquindox to aquatic organisms.
奥拉喹多司是一种用于促进生产动物生长的饲料添加剂。作为已被禁用的药用饲料添加剂，动物饲料和水中的奥拉喹多司必须被视为一个重要的危害指标。为了提高对奥拉喹多司毒性的研究，我们对一种常见的淡水鱼类鲤鱼进行了奥拉喹多司毒性的毒理学研究。急性毒性试验结果表明，鲤鱼经口摄入奥拉喹多司的 7d-LD 为 3746.3mg/kg。我们还发现，奥拉喹多司在鲤鱼体内的积累系数为 1.45-1.9。基于研究的血液学和血液生化参数（红细胞计数、血红蛋白含量、ALT、AST 和 SOD 活性），我们发现奥拉喹多司在所有研究参数中均引起了显著的变化。关于生物蓄积性，结果表明奥拉喹多司更有效地内化到鱼类组织（肝脏、肾脏和肌肉）中。中毒鱼组织的组织病理学研究显示出各种变化，这些变化在适应反应和永久性组织损伤之间有所不同。我们的研究结果表明，奥拉喹多司对鲤鱼具有毒性，并且具有明显的蓄积性，鲤鱼急性和亚急性毒性试验的所有数据都可能为评估奥拉喹多司对水生生物的毒性提供有用的工具。
