Nesković N K, Elezović I, Karan V, Poleksić V, Budimir M
Institute for Plant Protection, Department of Toxicology, Belgrade, Yugoslavia.
Ecotoxicol Environ Saf. 1993 Apr;25(2):173-82. doi: 10.1006/eesa.1993.1016.
Investigations of acute and subacute atrazine toxicity in carp (Cyprinus carpio L.) were carried out. Acute toxicity was investigated in a semi-static test during a 96-hr exposition. The estimated LC-50 value was 18.8 mg/l. Subacute toxicity was investigated by exposing fish (carp) to different atrazine concentrations (1.5, 3.0, and 6.0 mg/l) for 14 days. Biochemical and histopathological changes in certain organs and tissues were investigated. The results show that atrazine leads to changes of varying intensity depending on the parameter tested, the organs and tissues examined, as well as the atrazine concentration. Biochemical changes were most prominent in the alkaline phosphatase, glutamic-oxaloacetic transaminase, and glutamic-pyruvic transaminase activities whereas the most severe histopathological changes were observed in the gills.
开展了鲤鱼（Cyprinus carpio L.）急性和亚急性莠去津毒性研究。在一项为期96小时的半静态试验中研究了急性毒性。估计的半数致死浓度（LC-50）值为18.8毫克/升。通过将鱼类（鲤鱼）暴露于不同浓度（1.5、3.0和6.0毫克/升）的莠去津中14天来研究亚急性毒性。研究了某些器官和组织的生化及组织病理学变化。结果表明，根据所测试的参数、所检查的器官和组织以及莠去津浓度，莠去津会导致不同强度的变化。生化变化在碱性磷酸酶、谷草转氨酶和谷丙转氨酶活性方面最为显著，而鳃中观察到最严重的组织病理学变化。
