Kosaki Keisei, Kamijo-Ikemori Atsuko, Sugaya Takeshi, Tanahashi Koichiro, Akazawa Nobuhiko, Hibi Chihiro, Nakamura Takashi, Murase Takayo, Kimura Kenjiro, Shibagaki Yugo, Maeda Seiji
Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki 305-8577, Japan.
Division of Nephrology and Hypertension, Department of Internal Medicine, St. Marianna University School of Medicine, Kanagawa 216-8511, Japan.
J Clin Biochem Nutr. 2018 May;62(3):247-253. doi: 10.3164/jcbn.17-101. Epub 2018 Mar 30.
The aim of present study was to investigate the association between plasma xanthine oxidoreductase activity, which has gained attention as a novel preventive target of cardiovascular disease, and various physiological parameters and was to determine the effects of habitual exercise on plasma xanthine oxidoreductase activity in middle-aged and older women. In the cross-sectional study, we investigated the association between plasma xanthine oxidoreductase activity and various physiological parameters in 94 middle-aged and older women. In the interventional study, subjects ( = 22) were divided into two groups: exercise ( = 12) or the control group ( = 10), whereby we examined the effect of 12-week aerobic exercise training on plasma xanthine oxidoreductase activity in middle-aged and older women. The cross-sectional study demonstrated that plasma xanthine oxidoreductase activity was significantly associated with various physiological parameters, including visceral fat and daily step counts. In the interventional study, the plasma xanthine oxidoreductase activity significantly decreased after the 12-week aerobic exercise training, its changes were inversely associated with the changes in daily step counts. Our results revealed that the plasma xanthine oxidoreductase activity was associated with visceral fat accumulation and lack of exercise, and it was decreased by the aerobic exercise training.
本研究的目的是调查作为心血管疾病新预防靶点而受到关注的血浆黄嘌呤氧化还原酶活性与各种生理参数之间的关联，并确定习惯性运动对中老年女性血浆黄嘌呤氧化还原酶活性的影响。在横断面研究中，我们调查了94名中老年女性血浆黄嘌呤氧化还原酶活性与各种生理参数之间的关联。在干预性研究中，受试者（n = 22）被分为两组：运动组（n = 12）或对照组（n = 10），据此我们研究了为期12周的有氧运动训练对中老年女性血浆黄嘌呤氧化还原酶活性的影响。横断面研究表明，血浆黄嘌呤氧化还原酶活性与包括内脏脂肪和每日步数在内的各种生理参数显著相关。在干预性研究中，为期12周的有氧运动训练后血浆黄嘌呤氧化还原酶活性显著降低，其变化与每日步数的变化呈负相关。我们的结果显示，血浆黄嘌呤氧化还原酶活性与内脏脂肪堆积和缺乏运动有关，有氧运动训练可使其降低。
