Kang Yang, Ma Yuan, Zhang Sheng, Ding Li-Sheng, Li Bang-Jing
Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China.
State Key Laboratory of Polymer Materials Engineering, Polymer Research Institute of Sichuan University, Sichuan University, Chengdu 610065, China.
ACS Macro Lett. 2015 May 19;4(5):543-547. doi: 10.1021/acsmacrolett.5b00171. Epub 2015 Apr 21.
Two end-decorated homopolymers, methoxy polyethylene glycol-ferrocene (mPEG-Fc) and poly(-isopropylacrylamide)-β-cyclodextrin (PNIPAM-β-CD), were further orthogonally self-assembled into stable micelles in aqueous solution by controlling the temperature of the solution via terminal host-guest interactions. Because of the HO cleavable CD/Fc connection and thermoresponsive PNIPAM, an HO and thermo dual-controlled drug release based on this system was also achieved. Interestingly, the cytotoxicity evaluation of mPEG-Fc/PNIPAM-β-CD indicated good biocompatibility. Compared with free doxorubicin, the doxorubicin-loaded supramolecular micelles exhibited equal cellular proliferation inhibition toward A549 cells. This supramolecular complex is thus anticipated to serve as a promising new type of alternative drug-delivery system.
两种末端修饰的均聚物，甲氧基聚乙二醇 - 二茂铁（mPEG - Fc）和聚（N - 异丙基丙烯酰胺）-β-环糊精（PNIPAM - β - CD），通过末端主客体相互作用控制溶液温度，在水溶液中进一步正交自组装成稳定的胶束。由于HO可裂解的环糊精/二茂铁连接和热响应性的聚N - 异丙基丙烯酰胺，基于该系统还实现了HO和热双控药物释放。有趣的是，mPEG - Fc/PNIPAM - β - CD的细胞毒性评估表明其具有良好的生物相容性。与游离阿霉素相比，负载阿霉素的超分子胶束对A549细胞表现出同等的细胞增殖抑制作用。因此，这种超分子复合物有望成为一种有前途的新型替代药物递送系统。
