Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization, Chengdu Institute of Biology, Chinese Academy of Sciences , Chengdu 610041, Sichuan, China.
State Key Laboratory of Polymer Materials Engineering (Sichuan University), Polymer Research Institute of Sichuan University , Chengdu 610065, Sichuan, China.
ACS Appl Mater Interfaces. 2017 Feb 8;9(5):4475-4484. doi: 10.1021/acsami.6b14640. Epub 2017 Jan 30.
A dual redox and biorelevant triggered supramolecular system is developed through noncovalent supramolecular inclusion interactions between the ferrocene (Fc) modified on camptothecin (CPT) and β-cyclodextrin (β-CD) at the end of methoxy polyethylene glycol (mPEG). With these two segments, a stable noncovalent supramolecular structure, i.e., mPEG-β-CD/Fc-CPT, can be formed, and then self-assembled into micellar structures in water. Interestingly, these supramolecular micelles showed uniform sphere structure, high and constant drug loading content, hyper-fast redox-responsive drug release, and exhibited equal cellular proliferation inhibition toward A549 cancer cells. The cytotoxicity evaluation of mPEG-β-CD also indicated good biocompatibility. In vivo results revealed the mPEG-β-CD/Fc-CPT nanoparticles had higher in vivo efficacy without side effects. It is anticipated this supramolecular complex may serve as a new kind of promising alternative for drug delivery systems.
通过在甲氧基聚乙二醇（mPEG）末端的喜树碱（CPT）上的二茂铁（Fc）修饰与β-环糊精（β-CD）之间的非共价超分子包合相互作用，开发了一种双重氧化还原和生物相关触发的超分子系统。有了这两个部分，可以形成一个稳定的非共价超分子结构，即 mPEG-β-CD/Fc-CPT，然后在水中自组装成胶束结构。有趣的是，这些超分子胶束表现出均匀的球体结构、高且恒定的药物负载含量、超快速氧化还原响应药物释放，并对 A549 癌细胞表现出相等的细胞增殖抑制作用。mPEG-β-CD 的细胞毒性评估也表明了良好的生物相容性。体内结果表明，mPEG-β-CD/Fc-CPT 纳米颗粒具有更高的体内疗效而没有副作用。预计这种超分子复合物可能成为一种有前途的新型药物传递系统。
