Szpringer Monika, Oledzka Marzena, Amann Benedikt L
Faculty of Medicine and Health Sciences, Jan Kochanowski University, Kielce, Poland.
Institut de Neuropsiquiatria i Addiccions, Hospital del Mar, Centro Fórum Research Unit, Centro de Investigación Biomédica en Red de Salud Mental, Barcelona, Spain.
Front Psychol. 2018 May 22;9:785. doi: 10.3389/fpsyg.2018.00785. eCollection 2018.
Glioblastoma multiforme (GBM) is a highly aggressive brain cancer and its survival after diagnosis is less than 2 years. Therefore, GBM patients are especially prone to co-occurring psychological conditions such as anxiety and depressive disorders. Furthermore, aggressive medical therapies affect patients' lives, undermining their sense of meaning and coherence. The main aim of this study was to determine the effectiveness of Eye Movement Desensitization and Reprocessing (EMDR) therapy on anxiety, depression and sense of coherence in patients with GBM. Thirty-seven GBM-diagnosed women were included in this trial and received standard medical care. Of those, 18 patients were treated during 4 months with 10-12 individual EMDR sessions (60-90 minutes each). Nineteen GBM patients were used as a non-randomized control group as they consented to psychological evaluations but not to a psychotherapeutic intervention. The groups were homogeneous in terms of gender, age, educational level and treatment, but not in anxiety and depressive levels at baseline. All patients were evaluated at baseline, after treatment (4 months) and at follow-up (further 4 months) by the Hospital Anxiety and Depression Scale (HADS-M) and the Sense of Coherence Scale (SOC-29). Caregivers in both groups were interviewed by the Patient Caregiver Questionnaire after 4 months follow-up. Statistical analyses were conducted using ANOVA statistics, correlation and regression analysis. Results showed a statistically significant decrease in the EMDR group in anxiety, depression and anger, when compared to the experimental group. EMDR therapy also had a positive impact upon the sense of coherence level in the experimental group, whereas in the control group this declined. Finally, the caregivers reported beneficial outcomes of the EMDR therapy with less anxiety- and anger-related behaviors in patients in the experimental group compared to the control group. This study is the first to show beneficial effects of EMDR therapy in alleviating affective symptoms and improving coherence in a severe medically ill population with GBM.
多形性胶质母细胞瘤（GBM）是一种极具侵袭性的脑癌，确诊后的生存期不足2年。因此，GBM患者特别容易出现焦虑和抑郁障碍等并发心理状况。此外，积极的药物治疗会影响患者的生活，破坏他们的意义感和连贯感。本研究的主要目的是确定眼动脱敏再处理（EMDR）疗法对GBM患者焦虑、抑郁和连贯感的有效性。37名被诊断为GBM的女性纳入了该试验并接受标准医疗护理。其中，18名患者在4个月内接受了10 - 12次个体EMDR治疗（每次60 - 90分钟）。19名GBM患者作为非随机对照组，因为他们同意接受心理评估，但不同意接受心理治疗干预。两组在性别、年龄、教育水平和治疗方面具有同质性，但基线时的焦虑和抑郁水平不同。所有患者在基线、治疗后（4个月）和随访时（再4个月）通过医院焦虑抑郁量表（HADS - M）和连贯感量表（SOC - 29）进行评估。4个月随访后，通过患者护理问卷对两组的护理人员进行访谈。使用方差分析统计、相关性和回归分析进行统计分析。结果显示，与实验组相比，EMDR组的焦虑、抑郁和愤怒有统计学显著下降。EMDR疗法对实验组的连贯感水平也有积极影响，而对照组则下降。最后，护理人员报告称，与对照组相比，EMDR疗法对实验组患者产生了有益效果，患者焦虑和愤怒相关行为减少。本研究首次表明EMDR疗法在减轻患有GBM的重症患者情感症状和改善连贯感方面具有有益效果。
