McGinnity Colm J, Riaño Barros Daniela A, Trigg William, Brooks David J, Hinz Rainer, Duncan John S, Koepp Matthias J, Hammers Alexander
Division of Brain Sciences, Imperial College London, London, UK.
MRC Clinical Sciences Centre, London, UK.
EJNMMI Res. 2018 Jun 11;8(1):46. doi: 10.1186/s13550-018-0396-2.
The NMDA receptor radiotracer [F]GE-179 has been used with 90-min scans and arterial plasma input functions. We explored whether (1) arterial blood sampling is avoidable and (2) shorter scans are feasible.
For 20 existing [F]GE-179 datasets, we generated (1) standardised uptake values (SUVs) over eight intervals; (2) volume of distribution (V) images using population-based input functions (PBIFs), scaled using one parent plasma sample; and (3) V images using three shortened datasets, using the original parent plasma input functions (ppIFs).
Correlations with the original ppIF-derived 90-min Vs increased for later interval SUVs (maximal ρ = 0.78; 80-90 min). They were strong for PBIF-derived Vs (ρ = 0.90), but between-subject coefficient of variation increased. Correlations were very strong for the 60/70/80-min original ppIF-derived Vs (ρ = 0.97-1.00), which suffered regionally variant negative bias.
Where arterial blood sampling is available, reduction of scan duration to 60 min is feasible, but with negative bias. The performance of SUVs was more consistent across participants than PBIF-derived Vs.
NMDA受体放射性示踪剂[F]GE-179已用于90分钟的扫描及动脉血浆输入函数。我们探讨了（1）是否可避免动脉采血以及（2）更短时间的扫描是否可行。
对于20个现有的[F]GE-179数据集，我们生成了（1）八个时间间隔内的标准化摄取值（SUV）；（2）使用基于人群的输入函数（PBIF）生成分布容积（V）图像，该函数使用一份母体血浆样本进行缩放；以及（3）使用三个缩短的数据集生成V图像，使用原始的母体血浆输入函数（ppIF）。
后期时间间隔的SUV与原始ppIF衍生的90分钟V值的相关性增加（最大ρ = 0.78；80 - 90分钟）。PBIF衍生的V值相关性很强（ρ = 0.90），但受试者间变异系数增加。60/70/80分钟原始ppIF衍生的V值相关性非常强（ρ = 0.97 - 1.00），但存在区域变异的负偏差。
在可进行动脉采血的情况下，将扫描时间缩短至60分钟是可行的，但存在负偏差。SUV在不同参与者之间的表现比PBIF衍生的V值更一致。
