编码人白细胞介素2受体的cDNA在真核细胞中的稳定表达。
Stable expression of cDNA encoding the human interleukin 2 receptor in eukaryotic cells.
作者信息
Greene W C, Robb R J, Svetlik P B, Rusk C M, Depper J M, Leonard W J
出版信息
J Exp Med. 1985 Jul 1;162(1):363-8. doi: 10.1084/jem.162.1.363.
Abstract
Human interleukin 2 (IL-2) receptor cDNA derived from HUT 102B2 cells was stably expressed in murine L cells. These L cell transfectants (a) displayed surface receptors of the aberrant size of the IL-2 receptors on HUT 102B2 cells, (b) did not respond to exogenous IL-2 with augmented proliferation, and (c) expressed low affinity but not high affinity receptors for IL-2.
摘要
源自HUT 102B2细胞的人白细胞介素2（IL-2）受体cDNA在鼠L细胞中稳定表达。这些L细胞转染子：（a）表现出与HUT 102B2细胞上IL-2受体异常大小相同的表面受体；（b）对外源IL-2刺激的增殖反应无增强；（c）表达IL-2的低亲和力而非高亲和力受体。
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