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编码人白细胞介素2受体的cDNA在真核细胞中的稳定表达。

Stable expression of cDNA encoding the human interleukin 2 receptor in eukaryotic cells.

作者信息

Greene W C, Robb R J, Svetlik P B, Rusk C M, Depper J M, Leonard W J

出版信息

J Exp Med. 1985 Jul 1;162(1):363-8. doi: 10.1084/jem.162.1.363.

DOI:10.1084/jem.162.1.363
PMID:2989411
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2187706/
Abstract

Human interleukin 2 (IL-2) receptor cDNA derived from HUT 102B2 cells was stably expressed in murine L cells. These L cell transfectants (a) displayed surface receptors of the aberrant size of the IL-2 receptors on HUT 102B2 cells, (b) did not respond to exogenous IL-2 with augmented proliferation, and (c) expressed low affinity but not high affinity receptors for IL-2.

摘要

源自HUT 102B2细胞的人白细胞介素2（IL-2）受体cDNA在鼠L细胞中稳定表达。这些L细胞转染子：（a）表现出与HUT 102B2细胞上IL-2受体异常大小相同的表面受体；（b）对外源IL-2刺激的增殖反应无增强；（c）表达IL-2的低亲和力而非高亲和力受体。

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Stable expression of cDNA encoding the human interleukin 2 receptor in eukaryotic cells.编码人白细胞介素2受体的cDNA在真核细胞中的稳定表达。
J Exp Med. 1985 Jul 1;162(1):363-8. doi: 10.1084/jem.162.1.363.
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Purification and chemical characterization of the receptor for interleukin 2 from activated human T lymphocytes and from a human T-cell lymphoma cell line.从活化的人T淋巴细胞和人T细胞淋巴瘤细胞系中纯化白细胞介素2受体并进行化学表征。
Proc Natl Acad Sci U S A. 1984 Oct;81(20):6481-5. doi: 10.1073/pnas.81.20.6481.
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Characterization of the human receptor for T-cell growth factor.T细胞生长因子的人类受体的特性分析。
Proc Natl Acad Sci U S A. 1983 Nov;80(22):6957-61. doi: 10.1073/pnas.80.22.6957.
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Direct demonstration of the identity of T cell growth factor binding protein and the Tac antigen.T细胞生长因子结合蛋白与Tac抗原同一性的直接证明。
J Exp Med. 1983 Oct 1;158(4):1332-7. doi: 10.1084/jem.158.4.1332.
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Characterization of human interleukin 2 receptor (Tac antigen) in normal and leukemic T cells: co-expression of normal and aberrant receptors on Hut-102 cells.正常和白血病T细胞中人白细胞介素2受体（Tac抗原）的特性：Hut-102细胞上正常受体与异常受体的共表达
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