钩吻状日头草中的新穿心莲烷二萜和植物蜕皮甾酮及其对体外细胞毒性、超氧阴离子生成和弹性蛋白酶释放的影响评价。
Neo-clerodane diterpenes and phytoecdysteroids from Ajuga decumbens Thunb. and evaluation of their effects on cytotoxic, superoxide anion generation and elastase release in vitro.
机构信息
Department of Natural Medicinal Chemistry, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, China.
Department of Medical Science, Shunde Polytechnic, Foshan 528333, China; State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau SAR 999078, China.
出版信息
Fitoterapia. 2018 Sep;129:7-12. doi: 10.1016/j.fitote.2018.06.004. Epub 2018 Jun 9.
Five novel compounds, including four neoclerodane diterpenoids, named ajugacumbins KN (1-4) along with a phytoecdysterone, named ajugacetalsterone E (5), were isolated from the whole herbs of Ajuga decumbens (Labiatae). Their structures were elucidated on the basis of detailed spectroscopic analysis including IR, HRESIMS, CD, 1D and 2D NMR spectroscopic experiments. Compounds 1-5 were evaluated for their cytotoxic activities and the effects on superoxide anion generation and elastase release in FMLP/CB-induced human neutrophils.
从唇形科筋骨草属植物Ajuga decumbens 的全草中分离得到了 5 种新化合物，包括 4 种新的新穿心莲烷二萜，命名为 ajugacumbins KN（1-4），以及 1 种植物甾酮，命名为 ajugacetalsterone E（5）。基于包括 IR、HRESIMS、CD、1D 和 2D NMR 光谱实验在内的详细光谱分析，阐明了它们的结构。评估了化合物 1-5 的细胞毒性活性以及对 FMLP/CB 诱导的人中性粒细胞中超氧阴离子生成和弹性蛋白酶释放的影响。
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