Biologically Active Compounds in Inflorescences: Isolation, Phytochemical Characterization and Effects on the Skin Biophysical Parameters.

Three germacranolides, as well as five flavonoids, natural steroid and simple phenolic compounds, were isolated from the inflorescence of growing in Iran. The paper presents active compounds found for the first time in the inflorescence of this species. The flavonoids, simple phenolic compounds and natural steroids have been isolated for the first time in the genus . The MTT assay was employed to study in vitro cytotoxic effects of the taxifolin against human fibroblasts. We also evaluate the possible biological properties/cosmetic effects of extract and taxifolin on the human skin. Sixty healthy Caucasian adult females with no dermatological diseases were investigated. We evaluate the effects of extract and taxifolin on skin hydration and transepidermal water loss (TEWL). It was revealed that extract might decrease TEWL level and fixed the barrier function of the epidermis. The presence of bioactive phytochemical constituents in inflorescences makes them a valuable and safe source for creating new cosmetics and medicines.