Institute of Molecular Medicine, RWTH Aachen University, Aachen, Germany.
Department of Microbiology and Immunology, The University of Melbourne, Melbourne, Australia.
Sci Rep. 2018 Jun 12;8(1):8986. doi: 10.1038/s41598-018-27339-8.
During immune responses, T cells differentiate into subsets with different functions and migratory properties. Here we characterize migratory behavior of endogenous αβ CD8 and γδ T cells in lymph nodes by long-term tracking following in vivo photoconversion. We identified subsets of γδ T cells with distinct circulation kinetics that closely mirrored migratory subsets of αβ CD8 T cells. Notably, αβ CD8 and γδ T cells both comprised resident populations which stayed in lymph nodes for 4 weeks without circulation or proliferation. Furthermore, in contrast to the common conception, we observed that central memory αβ CD8 T cells circulate with slower kinetics than naïve cells. Our results show that, similar to αβ T cells, γδ T cells can acquire distinct migratory properties during their development and differentiation and reveal unexpected intricacies of T cell migratory patterns.
在免疫反应中，T 细胞会分化为具有不同功能和迁移特性的亚群。在这里，我们通过体内光转化后的长期追踪，描述了内源性 αβ CD8 和 γδ T 细胞在淋巴结中的迁移行为。我们鉴定出了具有不同循环动力学特征的 γδ T 细胞亚群，这些特征与 αβ CD8 T 细胞的迁移亚群非常相似。值得注意的是，αβ CD8 和 γδ T 细胞都包含驻留群体，它们在没有循环或增殖的情况下可以在淋巴结中停留 4 周。此外，与普遍的概念相反，我们观察到中央记忆性 αβ CD8 T 细胞的循环动力学比幼稚细胞更慢。我们的研究结果表明，与 αβ T 细胞类似，γδ T 细胞在其发育和分化过程中可以获得不同的迁移特性，并揭示了 T 细胞迁移模式的意想不到的复杂性。
