Feng Tong-Tong, Fu Hui-Zheng, Yang Yi-Sheng, Zhou Zhi-Qiang, Dai Mian, Bi Hong-Yu, Wang Dong
a Jiangxi Provincial Engineering Research Center for Drug and Medical Device Quality, Jiangxi Provincial Institute for Drug Control , Nanchang , China.
b Jiangxi University of Traditional Chinese Medicine , Nanchang , China.
Nat Prod Res. 2019 May;33(9):1269-1276. doi: 10.1080/14786419.2018.1470515. Epub 2018 Jun 13.
Two new noroleanane-type triterpenoid saponins, 3β,20α,24-trihydroxy-29-norolean-12-en-28-oic acid 24-O-β-L-fucopyranosyl-(1→2)-[β-D-xylopyranosyl-(1→3)]-β-D-glucopyranoside (1) and 3β,20α,24-trihydroxy-29-norolean-12-en-28-oic acid 24-O-β-D-glucopyranosyl-(1→2)-[α-L-arabinopyranosyl-(1→3)]-β-D-glucopyranoside (2) were isolated from the stems of Stauntonia chinensis DC., together with three known compounds, brachyantheraoside B (3), eupteleasaponin Ⅷ (4) and fargoside B (5). Their structures were elucidated by spectroscopic and chemical methods. The cytotoxic activities of compounds 1 and 2 were evaluated against five human tumor cell lines (HCT-116, HepG2, BGC-823, NCI-H1650, and A2780). Compounds 1 and 2 showed moderate cytotoxic activities toward the tested cell lines with IC values ranging from 12.71 to 32.04 μM.
从中华野木瓜（Stauntonia chinensis DC.）的茎中分离得到两个新的降羽扇豆烷型三萜皂苷，3β,20α,24-三羟基-29-降羽扇豆-12-烯-28-酸24-O-β-L-呋喃果糖基-(1→2)-[β-D-吡喃木糖基-(1→3)]-β-D-吡喃葡萄糖苷（1）和3β,20α,24-三羟基-29-降羽扇豆-12-烯-28-酸24-O-β-D-吡喃葡萄糖基-(1→2)-[α-L-吡喃阿拉伯糖基-(1→3)]-β-D-吡喃葡萄糖苷（2），以及三个已知化合物，短药野木瓜苷B（3）、领春木皂苷Ⅷ（4）和崖爬藤苷B（5）。通过光谱和化学方法阐明了它们的结构。评估了化合物1和2对五种人类肿瘤细胞系（HCT-116、HepG2、BGC-823、NCI-H1650和A2780）的细胞毒活性。化合物1和2对测试的细胞系显示出中等细胞毒活性，IC值范围为12.71至32.04 μM。
