桔梗根中的两种新三萜皂苷。

Two new triterpenoid saponins from the root of Platycodon grandiflorum.

作者信息

Ma Guoxu, Guo Wenjie, Zhao Lizi, Zheng Qingxia, Sun Zhaocui, Wei Jianhe, Yang Junshan, Xu Xudong

机构信息

Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100193, China.

出版信息

Chem Pharm Bull (Tokyo). 2013;61(1):101-4. doi: 10.1248/cpb.c12-00713.

DOI:10.1248/cpb.c12-00713

PMID:23302593

Abstract

Two new triterpenoid saponins, named platycodon A (3-O-β-D-glucopyranosyl-16-O-β-D-glucopyranosyl-2β,3β,16β,21β-tetrahydroxyolean-12-en-28-oic acid) and platycodon B (3-O-β-D-glucopyranosyl-16-O-β-D-xylopyranosyl-2β,3β,16β,21β-tetrahydroxyolean-12-en-28-oic acid) were isolated from the roots of Platycodon grandiflorum. The structures of these compounds were elucidated by means of various spectroscopic analyses. Compounds 1 and 2 were tested in HepG-2, A549 and DU145 human cancer cell lines and showed remarkable cytotoxic activities against HepG-2 and A549 cancer cell lines with IC(50) values ranging from 4.9 to 9.4 µM, but they displayed weak cytotoxic activities against DU145 cancer cell line with IC(50) values greater than 10 µM.

摘要

从桔梗（Platycodon grandiflorum）根部分离出两种新的三萜皂苷，分别命名为桔梗皂苷A（3 - O - β - D - 吡喃葡萄糖基 - 16 - O - β - D - 吡喃葡萄糖基 - 2β,3β,16β,21β - 四羟基齐墩果 - 12 - 烯 - 28 - 酸）和桔梗皂苷B（3 - O - β - D - 吡喃葡萄糖基 - 16 - O - β - D - 吡喃木糖基 - 2β,3β,16β,21β - 四羟基齐墩果 - 12 - 烯 - 28 - 酸）。通过各种光谱分析方法阐明了这些化合物的结构。化合物1和2在HepG - 2、A549和DU145人癌细胞系中进行了测试，对HepG - 2和A549癌细胞系显示出显著的细胞毒性活性，IC(50)值范围为4.9至9.4 μM，但对DU145癌细胞系显示出较弱的细胞毒性活性，IC(50)值大于10 μM。