Department of Biochemistry, Molecular and Cellular Biology, Georgetown University , Washington, DC.
Center for the Study of Sex Differences in Health, Aging and Disease, Georgetown University , Washington, DC.
Physiology (Bethesda). 2018 Jul 1;33(4):254-260. doi: 10.1152/physiol.00011.2018.
T-cell function in female animal models of hypertension is poorly understood since most research is conducted in males. Our findings in Dahl-salt-sensitive and Dahl salt-resistant rats support prior research showing sex-specific T-cell effects in the pathophysiology of hypertension. Further studies are needed to inform clinical studies in both sexes and to provide clues into immune mechanisms underlying susceptibility and resilience to developing hypertension and associated disease.
女性高血压动物模型中的 T 细胞功能尚未得到充分了解，因为大多数研究都是在男性中进行的。我们在 Dahl 盐敏感型和 Dahl 盐抵抗型大鼠中的发现支持了先前的研究结果，即高血压病理生理学中存在特定于性别的 T 细胞效应。需要进一步的研究来为两性的临床研究提供信息，并为易患和抵抗高血压及相关疾病的免疫机制提供线索。
