MacLachlan N J, Osburn B I, Stott J L, Ghalib H W
Prog Clin Biol Res. 1985;178:79-84.
Direct inoculation of 85-125 day bovine fetuses with 4 serotypes of bluetongue virus (BTV) or 1 serotype of epizootic hemorrhagic disease virus (EHDV) resulted in either fetal death or teratogenesis. Three serotypes of BTV, and 1 of EHDV caused a similar cavitating encephalopathy, the severity of which likely reflected gestational age of the fetus at infection. Virus-specific antibody was readily detected in precolostral serum samples from all inoculated fetuses that survived until term, whereas, virus was not recovered from any of these calves. Calves with severe Orbivirus induced cerebral malformations would have poor viability, and they could not be expected to have any significance as virus reservoirs.
用4种血清型的蓝舌病病毒（BTV）或1种血清型的流行性出血病病毒（EHDV）直接接种85 - 125日龄的牛胎儿，会导致胎儿死亡或致畸。3种血清型的BTV和1种血清型的EHDV会引起类似的空泡性脑病，其严重程度可能反映了感染时胎儿的胎龄。在所有存活至足月的接种胎儿的初乳前血清样本中很容易检测到病毒特异性抗体，而在这些小牛中均未分离到病毒。患有严重环状病毒诱导的脑畸形的小牛生存能力较差，预计它们作为病毒储存宿主没有任何意义。
