Veeramohan Rubashiny, Azizan Kamalrul Azlan, Aizat Wan Mohd, Goh Hoe-Han, Mansor Sharif Mahsufi, Yusof Nur Sabrina Mohd, Baharum Syarul Nataqain, Ng Chyan Leong
Institute of Systems Biology (INBIOSIS), Universiti Kebangsaan Malaysia (UKM), 43600 Bangi, Selangor, Malaysia.
Centre for Drug Research, Universiti Sains Malaysia, 11800 Minden, Penang, Malaysia.
Data Brief. 2018 Apr 4;18:1212-1216. doi: 10.1016/j.dib.2018.04.001. eCollection 2018 Jun.
is a psychoactive plant known as "ketum" in Malaysia and "kratom" in Thailand. This plant is distinctly known to produce two important alkaloids, namely mitragynine (MG) and 7-hydroxymitragynine (7-OH-MG) that can bind to opioid receptors [1]. MG was reported to exhibit antidepressant properties in animal studies [2]. These compounds were also proposed to have the potential to replace opioid analgesics with much lower risks of side effects [3]. To date, there are only over 40 metabolites identified in [4,5]. To obtain a more complete profile of secondary metabolites in ketum, we performed metabolomics study using mature leaves of the green variety. The leaf samples were extracted using methanol prior to liquid chromatography-electrospray ionization-time of flight-mass spectrometry (LC-ESI-TOF-MS) analysis. This data can be useful to for the identification of unknown metabolites that are associated with alkaloid biosynthesis pathway in .
是一种具有精神活性的植物，在马来西亚被称为“克他命”，在泰国被称为“ kratom”。这种植物因能产生两种重要的生物碱而闻名，即米托蒽醌（MG）和7-羟基米托蒽醌（7-OH-MG），它们可以与阿片受体结合[1]。据报道，MG在动物研究中具有抗抑郁特性[2]。这些化合物还被认为有可能替代阿片类镇痛药，且副作用风险低得多[3]。到目前为止，在[4,5]中仅鉴定出40多种代谢物。为了更全面地了解克他命中的次生代谢物，我们使用绿色品种的成熟叶片进行了代谢组学研究。在进行液相色谱-电喷雾电离-飞行时间质谱（LC-ESI-TOF-MS）分析之前，先用甲醇提取叶片样品。该数据有助于鉴定与克他命中生物碱生物合成途径相关的未知代谢物。
