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关于心材和叶提取物对[具体细胞系1]和[具体细胞系2]细胞系抗癌活性的体外研究数据。

In vitro studies data on anticancer activity of heartwood and leaf extracts on and cell lines.

作者信息

Naik Bukke Arunkumar, Nazneen Hadi Fathima, Babu K Suresh, Shankar P Chandramati

机构信息

Department of Biotechnology, Yogi Vemana University, Kadapa, Andhra Pradesh, India.

Natural Products Laboratory, Division of Natural Products Chemistry, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India.

出版信息

Data Brief. 2018 May 21;19:868-877. doi: 10.1016/j.dib.2018.05.050. eCollection 2018 Aug.

DOI:10.1016/j.dib.2018.05.050
PMID:29900385
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5997910/
Abstract

This article contains data on in vitro cytotoxicity activity of chloroform, methanolic and water extracts of leaf and heartwood of a medicinal plant against Breast cancer (MCF-7) and Lung cancer (A-549) cells. This data shows that Brazilin A, a natural bioactive compound in heartwood of induced cell death in breast cancer (MCF-7) cells. The therapeutic property was further proved by docking the Brazilin A molecule against BCL-2 protein (an apoptotic inhibitor) using auto dock tools.

摘要

本文包含一种药用植物叶片和心材的氯仿、甲醇和水提取物对乳腺癌（MCF-7）和肺癌（A-549）细胞的体外细胞毒性活性数据。该数据表明，巴西苏木素A，一种存在于心材中的天然生物活性化合物，可诱导乳腺癌（MCF-7）细胞死亡。通过使用自动对接工具将巴西苏木素A分子与BCL-2蛋白（一种凋亡抑制剂）进行对接，进一步证明了其治疗特性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36f1/5997910/8863ecd70457/mmc1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36f1/5997910/9d14508fc5ff/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36f1/5997910/c5067b3cc1a4/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36f1/5997910/27eecec10cfe/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36f1/5997910/61f494babb71/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36f1/5997910/91014d76b178/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36f1/5997910/2c8d877e86a8/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36f1/5997910/7727f8dc453a/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36f1/5997910/f1a6ba7303be/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36f1/5997910/8863ecd70457/mmc1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36f1/5997910/9d14508fc5ff/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36f1/5997910/c5067b3cc1a4/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36f1/5997910/27eecec10cfe/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36f1/5997910/61f494babb71/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36f1/5997910/91014d76b178/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36f1/5997910/2c8d877e86a8/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36f1/5997910/7727f8dc453a/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36f1/5997910/f1a6ba7303be/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36f1/5997910/8863ecd70457/mmc1.jpg

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