人乳头瘤病毒16型DNA序列。
Human papillomavirus type 16 DNA sequence.
作者信息
Seedorf K, Krämmer G, Dürst M, Suhai S, Röwekamp W G
出版信息
Virology. 1985 Aug;145(1):181-5. doi: 10.1016/0042-6822(85)90214-4.
The complete nucleotide sequence of HPV16 DNA (7904 bp) cloned from an invasive cervical carcinoma was determined. Homology comparisons allowed us to align the major open reading frames with the other published papilloma virus DNA sequences. The general organization of the open reading frames is similar to that of the other four papillomavirus (BPV1, HPV1a, HPV6b, CRPV) already sequenced. The sequence reveals an interruption of the reading frame coding for a suspected E1 protein.
测定了从一例浸润性宫颈癌中克隆出的HPV16 DNA（7904碱基对）的完整核苷酸序列。同源性比较使我们能够将主要开放阅读框与其他已发表的乳头瘤病毒DNA序列进行比对。开放阅读框的总体结构与其他已测序的四种乳头瘤病毒（BPV1、HPV1a、HPV6b、CRPV）相似。该序列显示编码一种疑似E1蛋白的阅读框存在中断。
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