Kirii Y, Iwamoto S, Matsukura T
Kanebo Institute for Cancer Research, Osaka, Japan.
Virology. 1991 Nov;185(1):424-7. doi: 10.1016/0042-6822(91)90791-9.
The complete nucleotide sequence of human papillomavirus type 58 (HPV 58) DNA cloned from an invasive cervical carcinoma was determined. The HPV 58 genome consists of 7824 nucleotides, containing 37.9% of GC residues, and has a similar genome organization of other HPVs. On the nucleotide sequence level, it conserves the signal sequences for regulation of gene expression as with other genital HPVs and exhibits an extensive homology with HPV 33 (77%). Comparative analysis of amino acid sequences reveals that HPV 58 is closely related with HPVs 16, 31, and 33, and is more distantly related with HPVs 6, 11, 18, and 39. HPVs 58, 16, 31, and 33 can be regarded as a group in HPV.
测定了从一例浸润性宫颈癌中克隆出的人乳头瘤病毒58型（HPV 58）DNA的完整核苷酸序列。HPV 58基因组由7824个核苷酸组成，GC残基含量为37.9%，并且具有与其他HPV相似的基因组结构。在核苷酸序列水平上，它与其他生殖道HPV一样保留了用于调节基因表达的信号序列，并且与HPV 33具有广泛的同源性（77%）。氨基酸序列的比较分析表明，HPV 58与HPV 16、31和33密切相关，而与HPV 6、11、18和39的关系较远。HPV 58、16、31和33在HPV中可被视为一组。
