Dept. Immunology, University of Toronto, 1 King's College Circle, Medical Sciences Bldg., Toronto, Ontario M5S 1A8, Canada; Toronto General Hospital Research Institute, University Health Network, 67 College Street, Toronto, Ontario M5G 2M1, Canada.
Cytokine. 2018 Sep;109:57-64. doi: 10.1016/j.cyto.2018.02.010.
Accumulating evidence indicates that chemokine-chemokine receptor interactions invoke biological responses beyond their originally described function of orchestrating leukocyte trafficking. In this review we will extend the findings that chemokines participate actively in the neoplastic process, and consider the contribution of CCL5 activation of CCR5 on breast cancer cells to upregulation of anabolic metabolic events that would support the energy demands of cell replication and proliferation.
越来越多的证据表明，趋化因子-趋化因子受体相互作用引发的生物学反应超出了它们最初描述的协调白细胞迁移的功能。在这篇综述中，我们将扩展趋化因子积极参与肿瘤发生过程的发现，并考虑 CCL5 激活乳腺癌细胞上的 CCR5 对上调合成代谢事件的贡献，这些事件将支持细胞复制和增殖的能量需求。
