Pollard Victoria A, Fuentes M Ángeles, Kennedy Alan R, McLellan Ross, Mulvey Robert E
WestCHEM, Department of Pure and Applied Chemistry, University of Strathclyde, Glasgow, G1 1XL, UK.
Angew Chem Int Ed Engl. 2018 Aug 13;57(33):10651-10655. doi: 10.1002/anie.201806168. Epub 2018 Jul 9.
Bimetallic lithium aluminates and neutral aluminum counterparts are compared as catalysts in hydroboration reactions with aldehydes, ketones, imines and alkynes. Possessing Li-Al cooperativity, ate catalysts are found to be generally superior. Catalytic activity is also influenced by the ligand set, alkyl and/or amido. Devoid of an Al-H bond, iBu Al(TMP) operates as a masked hydride reducing benzophenone through a β-Η transfer process. This catalyst library therefore provides an entry point into the future design of Al catalysts targeting substrate specific transformations.
将双金属锂铝酸盐和中性铝类似物作为醛、酮、亚胺和炔烃硼氢化反应的催化剂进行了比较。发现具有锂-铝协同作用的铝酸酯催化剂通常更具优势。催化活性也受配体、烷基和/或酰胺基的影响。异丁基铝（TMP）没有铝-氢键，通过β-氢转移过程作为一种掩蔽的氢化物还原二苯甲酮。因此，该催化剂库为未来设计针对特定底物转化的铝催化剂提供了一个切入点。
