University of Notre Dame, Department of Psychology, 118 Haggar Hall, Notre Dame, IN 46556, USA.
University of Notre Dame, Department of Psychology, 118 Haggar Hall, Notre Dame, IN 46556, USA.
Neurobiol Learn Mem. 2019 Apr;160:48-57. doi: 10.1016/j.nlm.2018.06.005. Epub 2018 Jun 12.
Information that is the most salient and important for future use is preferentially preserved through active processing during sleep. Emotional salience is a biologically adaptive cue that influences episodic memory processing through interactions between amygdalar and hippocampal activity. However, other cues that influence the importance of information, such as the explicit direction to remember or forget, interact with the inherent salience of information to determine its fate in memory. It is unknown how sleep-based processes selectively consolidate this complex information. The current study examined the development of memory for emotional and neutral information that was either cued to-be-remembered (TBR) or to-be-forgotten (TBF) across a daytime period including either napping or wakefulness. Baseline memory revealed dominance of the TBR cue, regardless of emotional salience. As anticipated, napping was found to preserve memory overall significantly better than remaining awake. Furthermore, we observed a trending interaction indicating that napping specifically enhanced the discrimination between the most salient information (negative TBR items) over other information. We found that memory for negative items was positively associated with the percentage of SWS obtained during a nap. Furthermore, the magnitude of the difference in memory between negative TBR items and negative TBF items increased with greater sleep spindle activity. Taken together, our results suggest that although the cue to actively remember or intentionally forget initially wins out, active processes during sleep facilitate the competition between salience cues to promote the most salient information in memory.
对于未来使用而言最重要和最突出的信息，通过睡眠期间的主动处理而被优先保留。情绪显著性是一种生物适应性线索，通过杏仁核和海马体活动之间的相互作用影响情景记忆处理。然而，其他影响信息重要性的线索，例如明确的记忆或遗忘的指令，与信息固有的显著性相互作用，以确定其在记忆中的命运。睡眠相关的过程如何选择性地巩固这种复杂的信息尚不清楚。本研究考察了在白天包括小睡或清醒在内的时间内，对情绪和中性信息的记忆发展，这些信息被提示要记住（TBR）或忘记（TBF）。基线记忆显示 TBR 线索占主导地位，无论情绪显著性如何。正如预期的那样，小睡被发现总体上比保持清醒更好地保存记忆。此外，我们观察到一个趋势性的相互作用，表明小睡特别增强了对最显著信息（负面 TBR 项目）与其他信息之间的区分。我们发现，对负面项目的记忆与小睡期间获得的慢波睡眠百分比呈正相关。此外，负面 TBR 项目和负面 TBF 项目之间记忆差异的幅度随着睡眠纺锤波活动的增加而增加。总之，我们的结果表明，尽管主动记住或故意忘记的线索最初占据优势，但睡眠期间的主动过程促进了显著性线索之间的竞争，以促进记忆中最显著的信息。
