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利用数值强度相关技术在光谱域光学相干断层扫描中实现全深度色散消除。

All-depth dispersion cancellation in spectral domain optical coherence tomography using numerical intensity correlations.

机构信息

Technical University of Denmark, DTU Fotonik, Kongens Lyngby, 2800, Denmark.

NKT Photonics, Birkerød, 3460, Denmark.

出版信息

Sci Rep. 2018 Jun 15;8(1):9170. doi: 10.1038/s41598-018-27388-z.

DOI:10.1038/s41598-018-27388-z
PMID:29907767
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6003914/
Abstract

In ultra-high resolution (UHR-) optical coherence tomography (OCT) group velocity dispersion (GVD) must be corrected for in order to approach the theoretical resolution limit. One approach promises not only compensation, but complete annihilation of even order dispersion effects, and that at all sample depths. This approach has hitherto been demonstrated with an experimentally demanding 'balanced detection' configuration based on using two detectors. We demonstrate intensity correlation (IC) OCT using a conventional spectral domain (SD) UHR-OCT system with a single detector. IC-SD-OCT configurations exhibit cross term ghost images and a reduced axial range, half of that of conventional SD-OCT. We demonstrate that both shortcomings can be removed by applying a generic artefact reduction algorithm and using analytic interferograms. We show the superiority of IC-SD-OCT compared to conventional SD-OCT by showing how IC-SD-OCT is able to image spatial structures behind a strongly dispersive silicon wafer. Finally, we question the resolution enhancement of [Formula: see text] that IC-SD-OCT is often believed to have compared to SD-OCT. We show that this is simply the effect of squaring the reflectivity profile as a natural result of processing the product of two intensity spectra instead of a single spectrum.

摘要

在超高分辨率(UHR-)光学相干断层扫描(OCT)中,为了接近理论分辨率极限,必须校正群速度色散(GVD)。一种方法不仅承诺补偿,而且在所有样品深度上完全消除偶数阶色散效应。迄今为止,这种方法已经通过使用两个探测器的实验性要求很高的“平衡检测”配置来证明。我们使用传统的光谱域(SD)UHR-OCT 系统结合单探测器展示了强度相关(IC)SD-OCT。IC-SD-OCT 配置表现出交叉项鬼影图像和轴向范围减小,只有传统 SD-OCT 的一半。我们通过应用通用伪影减少算法和使用分析干涉图来证明这两种缺点都可以消除。我们通过展示 IC-SD-OCT 如何能够对强色散硅晶片后面的空间结构进行成像,展示了与传统 SD-OCT 相比,IC-SD-OCT 的优越性。最后,我们质疑 IC-SD-OCT 通常被认为比 SD-OCT 具有更高的分辨率增强。我们表明,这仅仅是由于处理两个强度谱的乘积而不是单个谱的结果,将反射率轮廓平方的效果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee3b/6003914/3c577ddaae39/41598_2018_27388_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee3b/6003914/fc9982a488de/41598_2018_27388_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee3b/6003914/71ce6c22d141/41598_2018_27388_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee3b/6003914/c6066f46a56e/41598_2018_27388_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee3b/6003914/f9aa1cd5fba8/41598_2018_27388_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee3b/6003914/d7fb265861e9/41598_2018_27388_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee3b/6003914/3c577ddaae39/41598_2018_27388_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee3b/6003914/fc9982a488de/41598_2018_27388_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee3b/6003914/71ce6c22d141/41598_2018_27388_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee3b/6003914/c6066f46a56e/41598_2018_27388_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee3b/6003914/f9aa1cd5fba8/41598_2018_27388_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee3b/6003914/d7fb265861e9/41598_2018_27388_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee3b/6003914/3c577ddaae39/41598_2018_27388_Fig6_HTML.jpg

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