使用1000 - 1600纳米光谱波段的超高分辨率光谱域光学相干断层扫描技术。
Ultrahigh resolution spectral-domain optical coherence tomography using the 1000-1600 nm spectral band.
作者信息
Bernstein Liane, Ramier Antoine, Wu Jiamin, Aiello Vera D, Béland Marie J, Lin Charles P, Yun Seok-Hyun
机构信息
Wellman Center for Photomedicine, Massachusetts General Hospital, 50 Blossom Street, Boston, MA 02140, USA.
Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, USA.
出版信息
Biomed Opt Express. 2022 Mar 8;13(4):1939-1947. doi: 10.1364/BOE.443654. eCollection 2022 Apr 1.
Ultrahigh resolution optical coherence tomography (UHR-OCT) can image microscopic features that are not visible with the standard OCT resolution of 5-15 µm. In previous studies, high-speed UHR-OCT has been accomplished within the visible (VIS) and near-infrared (NIR-I) spectral ranges, specifically within 550-950 nm. Here, we present a spectral domain UHR-OCT system operating in a short-wavelength infrared (SWIR) range from 1000 to 1600 nm using a supercontinuum light source and an InGaAs-based spectrometer. We obtained an axial resolution of 2.6 µm in air, the highest ever recorded in the SWIR window to our knowledge, with deeper penetration into tissues than VIS or NIR-I light. We demonstrate imaging of conduction fibers of the left bundle branch in freshly excised porcine hearts. These results suggest a potential for deep-penetration, ultrahigh resolution OCT in intraoperative applications.
超高分辨率光学相干断层扫描（UHR-OCT）能够对一些微观特征进行成像，而这些特征在标准的5-15微米分辨率的光学相干断层扫描中是不可见的。在之前的研究中，高速UHR-OCT已在可见光（VIS）和近红外（NIR-I）光谱范围内实现，具体为550-950纳米。在此，我们展示了一种光谱域UHR-OCT系统，该系统使用超连续光源和基于铟镓砷的光谱仪，在1000至1600纳米的短波红外（SWIR）范围内运行。我们在空气中获得了2.6微米的轴向分辨率，据我们所知，这是在SWIR窗口中记录到的最高分辨率，并且与VIS或NIR-I光相比，它对组织的穿透更深。我们展示了在新鲜切除的猪心脏中左束支传导纤维的成像。这些结果表明，在术中应用中，深度穿透、超高分辨率光学相干断层扫描具有潜力。
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