School of Biological Sciences, National Institute of Science Education and Research (NISER), HBNI, P.O. Bhimpur-Padanpur, Jatni, Khurdha, Odisha, 752050, India.
S. K. Dash Center of Excellence of Biosciences and Engineering & Technology (SKBET), Indian Institute of Technology Bhubaneswar, Bhubaneswar, Odisha, India.
Probiotics Antimicrob Proteins. 2019 Sep;11(3):887-904. doi: 10.1007/s12602-018-9436-5.
Gut microbiota play important role in maintaining health. Probiotics are believed to augment it further. We aimed at comparing effects of probiotics, Lactobacillus acidophilus (LA) and Bacillus clausii (BC) (a) on the gut microbiota abundance and diversity and (b) their contributions to control intestinal dysbiosis and inflammation in Th1- and Th2-biased mice following Salmonella infection. We report how could gut microbiota and the differential immune bias (Th1 or Th2) of the host regulate host responses when challenged with Salmonella typhimurium in the presence and absence of either of the probiotics. LA was found to be effective in ameliorating the microbial dysbiosis and inflammation caused by Salmonella infection, in Th1 (C57BL/6) and Th2 (BALB/c)-biased mouse. BC was able to ameliorate Salmonella-induced dysbiosis and inflammation in Th2 but not in Th1-biased mouse. These results may support probiotics LA as a treatment option in the case of Salmonella infection.
肠道微生物在维持健康方面发挥着重要作用。益生菌被认为可以进一步增强其作用。我们旨在比较益生菌嗜酸乳杆菌（LA）和芽孢杆菌（BC）（a）对肠道微生物丰度和多样性的影响，以及（b）它们在沙门氏菌感染后对 Th1 和 Th2 偏向性小鼠肠道菌群失调和炎症的控制作用。我们报告了在存在或不存在益生菌的情况下，肠道微生物群和宿主的差异免疫偏向（Th1 或 Th2）如何调节宿主对鼠伤寒沙门氏菌的反应。我们发现 LA 能够改善由沙门氏菌感染引起的微生物失调和炎症，在 Th1（C57BL/6）和 Th2（BALB/c）偏向性小鼠中均有效果。BC 能够改善 Th2 偏向性小鼠的沙门氏菌诱导的菌群失调和炎症，但不能改善 Th1 偏向性小鼠的菌群失调和炎症。这些结果可能支持 LA 益生菌作为沙门氏菌感染的治疗选择。
